# fdrtool: Estimate (Local) False Discovery Rates For Diverse Test... In fdrtool: Estimation of (Local) False Discovery Rates and Higher Criticism

## Description

`fdrtool` takes a vector of z-scores (or of correlations, p-values, or t-statistics), and estimates for each case both the tail area-based Fdr as well as the density-based fdr (=q-value resp. local false discovery rate). The parameters of the null distribution are estimated adaptively from the data (except for the case of p-values where this is not necessary).

## Usage

 ```1 2 3 4``` ```fdrtool(x, statistic=c("normal", "correlation", "pvalue"), plot=TRUE, color.figure=TRUE, verbose=TRUE, cutoff.method=c("fndr", "pct0", "locfdr"), pct0=0.75) ```

## Arguments

 `x` vector of the observed test statistics. `statistic` one of "normal" (default), "correlation", "pvalue". This species the null model. `plot` plot a figure with estimated densities, distribution functions, and (local) false discovery rates. `verbose` print out status messages. `cutoff.method` one of "fndr" (default), "pct0", "locfdr". `pct0` fraction of data used for fitting null model - only if `cutoff.method`="pct0" `color.figure` determines whether a color figure or a black and white figure is produced (defaults to "TRUE", i.e. to color figure).

## Details

The algorithm implemented in this function proceeds as follows:

1. A suitable cutoff point is determined. If `cutoff.method` is "fndr" then first an approximate null model is fitted and subsequently a cutoff point is sought with false nondiscovery rate as small as possible (see `fndr.cutoff`). If `cutoff.method` is "pct0" then a specified quantile (default value: 0.75) of the data is used as the cutoff point. If `cutoff.method` equals "locfdr" then the heuristic of the "locfdr" package (version 1.1-6) is employed to find the cutoff (z-scores and correlations only).

2. The parameters of the null model are estimated from the data using `censored.fit`. This results in estimates for scale parameters und and proportion of null values (`eta0`).

3. Subsequently the corresponding p-values are computed, and a modified `grenander` algorithm is employed to obtain the overall density and distribution function (note that this respects the estimated `eta0`).

4. Finally, q-values and local fdr values are computed for each case.

The assumed null models all have (except for p-values) one free scale parameter. Note that the z-scores and the correlations are assumed to have zero mean.

## Value

A list with the following components:

 `pval` a vector with p-values for each case. `qval` a vector with q-values (Fdr) for each case. `lfdr` a vector with local fdr values for each case. `statistic` the specified type of null model. `param` a vector containing the estimated parameters (the null proportion `eta0` and the free parameter of the null model).

## Author(s)

Korbinian Strimmer (https://strimmerlab.github.io).

## References

Strimmer, K. (2008a). A unified approach to false discovery rate estimation. BMC Bioinformatics 9: 303. <DOI:10.1186/1471-2105-9-303>

Strimmer, K. (2008b). fdrtool: a versatile R package for estimating local and tail area- based false discovery rates. Bioinformatics 24: 1461-1462. <DOI:10.1093/bioinformatics/btn209>

`pval.estimate.eta0`, `censored.fit`.

## Examples

 ``` 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26``` ```# load "fdrtool" library and p-values library("fdrtool") data(pvalues) # estimate fdr and Fdr from p-values data(pvalues) fdr = fdrtool(pvalues, statistic="pvalue") fdr\$qval # estimated Fdr values fdr\$lfdr # estimated local fdr # the same but with black and white figure fdr = fdrtool(pvalues, statistic="pvalue", color.figure=FALSE) # estimate fdr and Fdr from z-scores sd.true = 2.232 n = 500 z = rnorm(n, sd=sd.true) z = c(z, runif(30, 5, 10)) # add some contamination fdr = fdrtool(z) # you may change some parameters of the underlying functions fdr = fdrtool(z, cutoff.method="pct0", pct0=0.9) ```

### Example output

```Step 1... determine cutoff point
Step 2... estimate parameters of null distribution and eta0
Step 3... compute p-values and estimate empirical PDF/CDF
Step 4... compute q-values and local fdr
Step 5... prepare for plotting

[1] 0.2322881070 0.3896449272 0.0247528108 0.0234305698 0.0798729100
[6] 0.2484789712 0.0190579348 0.0815965680 0.1345016923 0.0431540421
[11] 0.1827582235 0.3642548055 0.0375952471 0.0335780783 0.0971899134
[16] 0.2304668692 0.1703179452 0.2712929857 0.0005576786 0.1433706745
[21] 0.0025983750 0.0588002587 0.2065280854 0.0013709230 0.0033396590
[26] 0.0099971427 0.0143938990 0.0056607119 0.0541200510 0.1357455993
[31] 0.0254207861 0.0084527680 0.3925335937 0.2858613936 0.0031736125
[36] 0.2975000546 0.2327660639 0.0720147698 0.2786099261 0.0993842828
[41] 0.2028542093 0.3628984401 0.1590623152 0.1142471762 0.0186247240
[46] 0.0512332045 0.0158908150 0.0398055920 0.3428508188 0.2303609176
[51] 0.3601724715 0.3096717628 0.3190143469 0.1597821425 0.0266592147
[56] 0.0726210174 0.2123020620 0.0012331836 0.0211484883 0.1121112098
[61] 0.2487119313 0.3743387773 0.0759982675 0.0004721100 0.1018721831
[66] 0.0004910251 0.0500836864 0.1665254503 0.0046880611 0.0076279668
[71] 0.0346416314 0.0053137628 0.0016184175 0.0538319034 0.3668418002
[76] 0.2931706712 0.0089499177 0.0006967314 0.1389051481 0.0182646038
[81] 0.0004733394 0.1260322756 0.1924575765 0.0486158838 0.0097763697
[86] 0.3752442043 0.2520444909 0.3087833442 0.0451960761 0.3400526548
[91] 0.0365141038 0.1062510442 0.2078286886 0.1824038999 0.2603414024
[96] 0.2556048314 0.0319242071 0.2938186865 0.3349648043 0.0046914236
[101] 0.1299392192 0.2618289723 0.0245808655 0.1644895620 0.2910815137
[106] 0.1871423574 0.3997963595 0.0676429655 0.3891266777 0.0211242801
[111] 0.0005209903 0.2704003573 0.0260705837 0.0369149951 0.1281042940
[116] 0.1551237176 0.2881162173 0.3512262847 0.0046529511 0.0900520354
[121] 0.3538102350 0.1856925287 0.1662170669 0.0050857627 0.0391875773
[126] 0.0062089209 0.0064033532 0.3066395309 0.0070012697 0.2331529152
[131] 0.2223290404 0.3581311913 0.0373973318 0.0097071405 0.2898011504
[136] 0.1571972624 0.0321435617 0.0018599046 0.0391674508 0.1333487591
[141] 0.0111198660 0.0056489394 0.0637772491 0.1753153967 0.0798402908
[146] 0.0541664204 0.1830807420 0.0020697300 0.1478569315 0.1020265124
[151] 0.3246142809 0.0110834542 0.0955539825 0.4103061591 0.0082149373
[156] 0.0705830145 0.1276369344 0.3590002872 0.3415914515 0.1171598449
[161] 0.3461945131 0.2947568632 0.3629598319 0.0096137975 0.0055457617
[166] 0.0045870513 0.2638262518 0.1045704819 0.1911973917 0.0931919384
[171] 0.1052074121 0.0828258128 0.0115203485 0.0106004391 0.0565768825
[176] 0.0354299372 0.0865517500 0.4093312813 0.1026746638 0.3792616446
[181] 0.0629344912 0.2039483054 0.2319243749 0.0867770522 0.1212475787
[186] 0.0894675345 0.1463208859 0.3516690633 0.3089074384 0.0533121025
[191] 0.2878778782 0.1421950874 0.0517767486 0.1360300973 0.2359885586
[196] 0.1651910297 0.0108984318 0.1810655914 0.0308582904 0.1242942184
[201] 0.0105422467 0.2043258610 0.1412797283 0.1978837687 0.0371435289
[206] 0.0661897626 0.3428608089 0.1842651496 0.0445836808 0.0028407027
[211] 0.3238932704 0.0023018621 0.0116731189 0.0090654688 0.0163568111
[216] 0.0753641459 0.0215682054 0.2175826420 0.0513402304 0.0004921172
[221] 0.0291611634 0.0003064018 0.0321041197 0.0296591920 0.0951093830
[226] 0.0518589679 0.0014471692 0.1352296670 0.0031589020 0.0615841809
[231] 0.0594076176 0.2578639889 0.1833882750 0.0706244949 0.1924260210
[236] 0.1597575294 0.1026812134 0.0910370657 0.1166798700 0.0938867827
[241] 0.1498652517 0.1254222399 0.2817754174 0.0938142584 0.0601376279
[246] 0.0445763143 0.0479793942 0.1977021301 0.1155830595 0.0052656795
[251] 0.0407226246 0.0239429179 0.2635594017 0.0036701817 0.2430619263
[256] 0.2083133620 0.0216068954 0.1015777009 0.2022761700 0.0811797632
[261] 0.0499652840 0.0067287700 0.1550922505 0.3728059686 0.0278903481
[266] 0.0142555163 0.0066190241 0.2110804561 0.0686250165 0.4103315058
[271] 0.0120074439 0.0019837211 0.3515272966 0.3058148511 0.2251517095
[276] 0.3052497121 0.0371211128 0.3307272149 0.1445467833 0.0005556404
[281] 0.2350271059 0.2046748438 0.0657444290 0.0082938238 0.1169354702
[286] 0.2666012313 0.0444588924 0.2519119409 0.1070658990 0.2822756795
[291] 0.2770726111 0.1938969293 0.0535269950 0.1813953159 0.1068477761
[296] 0.0309702111 0.2882785838 0.3127243767 0.0843590793 0.3870299859
[301] 0.2075409009 0.0701957533 0.3150152613 0.3764698090 0.0148831124
[306] 0.3356294326 0.3651571501 0.1456890397 0.0011029835 0.2638005131
[311] 0.0875691289 0.3158556205 0.1242616336 0.1686329614 0.1894164185
[316] 0.3771416116 0.2833468909 0.0092073907 0.1970437388 0.0302629731
[321] 0.3474401321 0.0444912766 0.0332414328 0.0703318482 0.1021550372
[326] 0.0011984593 0.0017023282 0.0876917426 0.2024944920 0.3751783926
[331] 0.0873239941 0.0402594068 0.2693389870 0.2681518310 0.3355746012
[336] 0.2566656164 0.1054531392 0.0092446342 0.2743423825 0.3376723007
[341] 0.1832907445 0.3441749975 0.2871153034 0.0931718193 0.3695554872
[346] 0.2819661944 0.0327584958 0.4023388631 0.1126798397 0.0525080823
[351] 0.2275762066 0.2997925361 0.0143416444 0.0734165253 0.1426374024
[356] 0.0065852426 0.2793521891 0.0173127122 0.2554349601 0.2739406201
[361] 0.0395502737 0.1443084814 0.2328416699 0.2819474482 0.2068531517
[366] 0.0923480926 0.0649271073 0.0198549665 0.2724904687 0.3671324395
[371] 0.1934546218 0.2497415382 0.0823296906 0.0467704627 0.2283826732
[376] 0.2766817344 0.1331434519 0.0005451152 0.0090445928 0.0324213394
[381] 0.0437683071 0.1538557803 0.3934279680 0.0345688772 0.0373438667
[386] 0.0032511777 0.0116507225 0.3455849722 0.1717021110 0.1021319739
[391] 0.0144267829 0.0588482243 0.0089056337 0.0765197819 0.1283279210
[396] 0.0773185892 0.1557751222 0.1417054160 0.0106595028 0.2477700460
[401] 0.2327222131 0.2451815258 0.1503018492 0.3473732579 0.1045324565
[406] 0.0380335994 0.1569194646 0.0569839176 0.0244457076 0.3613231906
[411] 0.1561416221 0.2550277285 0.1377304854 0.0200448582 0.1378689753
[416] 0.0033592247 0.1887354389 0.1029707245 0.3624390109 0.0838450505
[421] 0.0926416608 0.0274865689 0.2201991037 0.1838223550 0.1182478936
[426] 0.3107910408 0.0288253222 0.1509419043 0.2502922026 0.0762993094
[431] 0.3106826413 0.3426165312 0.1667876971 0.1376457431 0.3869343596
[436] 0.0528285962 0.1059615856 0.0023241982 0.0305134208 0.2607319142
[441] 0.0052458704 0.3671686414 0.1871781188 0.0894840167 0.4073491215
[446] 0.2567923033 0.3841511288 0.1069457515 0.1542429942 0.3414112725
[451] 0.2116151495 0.1649512371 0.1286550803 0.0278686171 0.0146836207
[456] 0.3325933911 0.3601262603 0.0062720037 0.0318350600 0.1842947499
[461] 0.2639713738 0.0324231202 0.1199247457 0.3078376366 0.0997343020
[466] 0.0215236120 0.0122253074 0.3353632355 0.0097366973 0.3387338195
[471] 0.2931895326 0.0594821233 0.1729197079 0.0601163117 0.2317451127
[476] 0.2957844273 0.1182368896 0.0914476837 0.1446411138 0.0035444436
[481] 0.1236699780 0.0095305189 0.4015883749 0.0215297845 0.0601370748
[486] 0.0475270269 0.0066932026 0.0062269175 0.0423712096 0.0648410425
[491] 0.0405624614 0.3833309740 0.3828003458 0.0718975382 0.2519515700
[496] 0.1197481618 0.2395226033 0.0865219153 0.0805403320 0.0140470795
[501] 0.2388430388 0.0091306803 0.0030473498 0.1061924466 0.3776034084
[506] 0.0923556927 0.2659996103 0.2875219285 0.3698467336 0.0011672002
[511] 0.0612457171 0.1272025141 0.2425424354 0.0547321813 0.3169533613
[516] 0.3881529845 0.1325827684 0.2532552835 0.0277099427 0.0079659688
[521] 0.0854803196 0.2596333562 0.0064199212 0.1736368311 0.0158515248
[526] 0.3238241789 0.1820508007 0.1607058473 0.0064399690 0.3066328934
[531] 0.3982344394 0.0017626723 0.0098154125 0.0044398290 0.0154371726
[536] 0.0205980903 0.0012471727 0.2834033813 0.3510522803 0.0323139464
[541] 0.2326720947 0.0406052680 0.2784595039 0.1333074832 0.2554754058
[546] 0.3601186907 0.1937369018 0.3851727651 0.2037934905 0.0344671238
[551] 0.0316008050 0.1157695282 0.1170358577 0.0881166015 0.2132949929
[556] 0.1140676224 0.1014995431 0.4001259858 0.2904426932 0.0331222803
[561] 0.1648266912 0.0016648085 0.2128701615 0.1152883947 0.2538545165
[566] 0.2692181810 0.0102548516 0.1925004969 0.0399799674 0.0114860066
[571] 0.0434790331 0.2473418017 0.0239865544 0.3737275595 0.3601570041
[576] 0.3062585718 0.0822970475 0.1398450538 0.0416350718 0.1764314805
[581] 0.0279418155 0.1122365346 0.1361091040 0.2115669077 0.1168263253
[586] 0.1806581658 0.3801977976 0.1461226077 0.1628695447 0.2624103916
[591] 0.0260079420 0.3711704514 0.3618236565 0.1470936229 0.0227389295
[596] 0.0153271213 0.3377220430 0.3665414515 0.0441522076 0.0304032400
[601] 0.0081924304 0.1656742660 0.0782536239 0.0689156175 0.2181650993
[606] 0.2947835453 0.0022528153 0.0612006909 0.1009841430 0.3243969084
[611] 0.0116262331 0.0733176796 0.1969575606 0.2404292423 0.0023130916
[616] 0.0338105908 0.0337763118 0.0674897339 0.0016074081 0.0387075487
[621] 0.2999695846 0.1965204044 0.2182243768 0.3268741798 0.0247118347
[626] 0.3375843694 0.0344743533 0.1113473957 0.0157573277 0.0322394438
[631] 0.0038068458 0.0701682519 0.0143689416 0.1486693630 0.0625131364
[636] 0.3520530161 0.0703267530 0.2625075950 0.4090997480 0.3174654540
[641] 0.3591331440 0.0053454322 0.0174139486 0.2594539080 0.1304768348
[646] 0.0189396882 0.0060083746 0.3622913198 0.2828076419 0.3676624429
[651] 0.3339955344 0.2907636493 0.0735360439 0.2058164031 0.1900398906
[656] 0.1422633363 0.0085224613 0.2936895952 0.0009611376 0.0421455657
[661] 0.3126924455 0.1532002416 0.0209986023 0.1730885253 0.0741344760
[666] 0.0022216703 0.0756861256 0.2444921436 0.2119318277 0.3216292588
[671] 0.2872238684 0.3507581814 0.0868221825 0.0268497903 0.1361341925
[676] 0.2496603485 0.0220889882 0.0716103788 0.0495320374 0.0732280165
[681] 0.0607700231 0.0289712279 0.0210538131 0.3157736530 0.1259628013
[686] 0.0015074464 0.0148385939 0.0793360156 0.2278182143 0.2501393806
[691] 0.1471621238 0.3377785652 0.0289892877 0.0061231738 0.0323520105
[696] 0.2578781302 0.0611079978 0.3969392126 0.0475261542 0.0581743766
[701] 0.0004699025 0.1466032809 0.0928847145 0.0511358948 0.3009628145
[706] 0.0250995857 0.0197338816 0.0863691974 0.1766317107 0.0031204498
[711] 0.2919766089 0.1663118918 0.0121744238 0.3796073950 0.3656240234
[716] 0.1998596006 0.3029096826 0.0119735633 0.2764600850 0.0488182570
[721] 0.2006845042 0.1752703917 0.0004939425 0.0440520144 0.0615989864
[726] 0.0301466188 0.1961598338 0.2210544630 0.3571033509 0.0030260756
[731] 0.0025190930 0.0053930000 0.0004710673 0.3419150484 0.0015471485
[736] 0.0037397929 0.3660303834 0.3433423963 0.0558193585 0.0434373521
[741] 0.3373539778 0.1317919247 0.4052664089 0.3296681562 0.4011516971
[746] 0.3460295365 0.3194314242 0.2226969991 0.0289508791 0.0741164746
[751] 0.0835417356 0.3114890389 0.2200705278 0.0842501707 0.1090397201
[756] 0.3622753973 0.0918089300 0.0113496119 0.3746210829 0.0312612198
[761] 0.0674710059 0.4102488313 0.0852663386 0.3404085963 0.1160050847
[766] 0.2396858713 0.2737938657 0.1339161750 0.0050959535 0.0895058407
[771] 0.3535189777 0.1412202421 0.1422686809 0.0692351357 0.1491078332
[776] 0.0194171833 0.0767052707 0.2115199460 0.2062077647 0.1592256705
[781] 0.2430364289 0.3939424711 0.1618591275 0.1543409787 0.0292726900
[786] 0.1364390174 0.2917329420 0.2812549049 0.2926199970 0.3987355917
[791] 0.3088193424 0.2675794872 0.1462727973 0.3284339695 0.3599149857
[796] 0.0345751580 0.1816964271 0.3190075790 0.1907027863 0.0057614191
[801] 0.0879633889 0.3324735570 0.0258655227 0.0268689098 0.0100230058
[806] 0.1545796117 0.2468593694 0.1596907259 0.0055577205 0.2196495099
[811] 0.1751492603 0.2610342106 0.2385646649 0.1194453795 0.2724028131
[816] 0.2096344964 0.2242417636 0.1135800648 0.0123565433 0.2851137960
[821] 0.2653631280 0.2287370388 0.2341272857 0.2921286157 0.3182383457
[826] 0.2001483982 0.0812728906 0.1225786363 0.0832213189 0.2534539534
[831] 0.0268475767 0.0435804932 0.0955509058 0.0783504616 0.2380704129
[836] 0.2177819179 0.2576166733 0.1467952174 0.0270867508 0.2724070805
[841] 0.1767399325 0.3987048267 0.2207448302 0.0406589037 0.0215965908
[846] 0.0822313952 0.3051869415 0.3866820671 0.0751994002 0.1550183945
[851] 0.2398111718 0.2178415722 0.3171507725 0.3319946317 0.0344565497
[856] 0.1132451793 0.0852223990 0.0140194365 0.1289362378 0.0212843594
[861] 0.0492114559 0.0115280883 0.0066637906 0.2879140566 0.0780196383
[866] 0.2252012795 0.2241201617 0.0156020209 0.2859152540 0.0880497889
[871] 0.1271288875 0.3994645774 0.1337907317 0.1974900957 0.0841335653
[876] 0.0429665539 0.2246963295 0.2498896124 0.3368107143 0.1246662282
[881] 0.4029512687 0.0222179169 0.1628132075 0.0937478403 0.0226229609
[886] 0.1122796296 0.1937269178 0.0177977818 0.0599693771 0.0781283205
[891] 0.3041188340 0.3023181528 0.0356275786 0.0580335999 0.1300077394
[896] 0.0838531401 0.0780131366 0.3300253078 0.2292887254 0.0667852442
[901] 0.0057883526 0.0323794680 0.0315986365 0.3483019103 0.0342742629
[906] 0.1400237730 0.2521421713 0.0367529449 0.1223290605 0.0412774102
[911] 0.2495759486 0.3993130904 0.2622445099 0.1663485764 0.3628413493
[916] 0.2754786366 0.2288058982 0.3735001904 0.4041179723 0.1949409083
[921] 0.0253904221 0.2289430663 0.0135362192 0.0292974827 0.3782641713
[926] 0.0485070984 0.1091418587 0.0295602509 0.3686533559 0.2858044088
[931] 0.0909262196 0.3852729522 0.2897822042 0.0640044952 0.1177596309
[936] 0.0179893703 0.0075001796 0.2789816388 0.1359260733 0.4008884385
[941] 0.1188731878 0.0246085849 0.0018053050 0.0848341737 0.2088112078
[946] 0.0437878242 0.0312656842 0.0353646160 0.0365169281 0.0235821146
[951] 0.1391048960 0.0648815913 0.0640873875 0.0449589601 0.1941688426
[956] 0.2053010758 0.1728292549 0.0207157407 0.0857595528 0.0149141929
[961] 0.4047566378 0.0572620105 0.1015763871 0.0743380526 0.3977319788
[966] 0.3427135794 0.3670980749 0.3812476266 0.2874300534 0.1098473910
[971] 0.2317076221 0.2036225333 0.1319450059 0.3581323125 0.0888517918
[976] 0.0163430857 0.0518584082 0.0752384318 0.2566687885 0.2033583491
[981] 0.1593562419 0.1259325319 0.3438013569 0.0202767393 0.0152418356
[986] 0.0037059041 0.0021254301 0.1431780849 0.1001704100 0.0025991295
[991] 0.0109350481 0.1715417955 0.0577070647 0.0029173253 0.0885483598
[996] 0.3176551699 0.0073726541 0.0127447012 0.0036888697 0.1478242709
[1001] 0.1514832608 0.3942312953 0.3432782722 0.0018894156 0.0056914966
[1006] 0.2713625421 0.0035347515 0.0129954820 0.2100149555 0.0297489443
[1011] 0.3512511279 0.0091926556 0.1286700452 0.1450873062 0.3939821834
[1016] 0.2315040687 0.0168526170 0.0298704335 0.3059606720 0.0028165147
[1021] 0.0075413247 0.0066616128 0.0018013677 0.0029069764 0.0323803289
[1026] 0.0317887578 0.1312142836 0.1680309910 0.0970486990 0.0137473994
[1031] 0.0334202758 0.0278215876 0.3986610479 0.0205289437 0.0748288318
[1036] 0.3806357158 0.1784432012 0.0149021364 0.0212141297 0.0085365543
[1041] 0.3062044203 0.0069640960 0.0036383349 0.3065087276 0.2840130659
[1046] 0.1538845986 0.4015123989 0.0788026350 0.0087215853 0.3389667551
[1051] 0.0004662576 0.2982458477 0.0004329081 0.0092305375 0.0821439857
[1056] 0.2418791564 0.2935294277 0.1778910682 0.3514969893 0.0554701177
[1061] 0.0010696704 0.0828909942 0.0276530008 0.1568508552 0.2414717012
[1066] 0.3977509546 0.2616820065 0.0463471095 0.0752920846 0.2869474636
[1071] 0.2947599185 0.3966889503 0.4007447038 0.1856721395 0.1263398244
[1076] 0.3664819538 0.1179510165 0.0818284364 0.2769356975 0.2442033784
[1081] 0.2107570653 0.0870489858 0.2614935149 0.0062375545 0.0162944316
[1086] 0.0692925811 0.2355179879 0.2913131473 0.4021639603 0.0101890052
[1091] 0.2670834406 0.2707066781 0.2985640582 0.1104423934 0.3833803381
[1096] 0.0328328446 0.0680073331 0.0754328923 0.0178776951 0.2212975891
[1101] 0.2141263439 0.1870630993 0.1016650687 0.0108785168 0.0793677830
[1106] 0.3144027566 0.0028078394 0.2066818968 0.1170484983 0.0082107191
[1111] 0.2968540017 0.1599344580 0.1959219013 0.0992005915 0.1230990071
[1116] 0.0268517625 0.3175946909 0.1957025058 0.0724458193 0.3558695005
[1121] 0.2402409368 0.0571565573 0.0900823457 0.2105368215 0.2383890673
[1126] 0.0755194235 0.0840347146 0.2755623521 0.3707862194 0.1599449365
[1131] 0.2905107343 0.1147025927 0.2626530257 0.0636144129 0.1473996279
[1136] 0.0060847047 0.0775868171 0.1718671086 0.0081469231 0.0339492508
[1141] 0.2746400819 0.1323719859 0.0058151357 0.3356487202 0.0650621207
[1146] 0.2938170818 0.3074958101 0.1836529813 0.2138051411 0.2229280721
[1151] 0.1050556448 0.3123640435 0.3389364298 0.1737196974 0.0159322138
[1156] 0.0042302603 0.2074038854 0.0510609165 0.0021066811 0.2676213974
[1161] 0.3552374661 0.0885476656 0.0110177113 0.0020612670 0.2665496198
[1166] 0.0004148359 0.0004913513 0.3110157719 0.1902113674 0.0121666126
[1171] 0.1374924264 0.1930771483 0.3080625083 0.3176754738 0.0072641319
[1176] 0.1919387894 0.0847729577 0.3321073468 0.3788934891 0.0507411881
[1181] 0.0574845191 0.0330281725 0.2014073120 0.2345976849 0.3315393474
[1186] 0.2036507605 0.0022698051 0.0143706724 0.0071985039 0.0515371071
[1191] 0.1396040367 0.2380869373 0.0166449691 0.3604417940 0.1576359910
[1196] 0.4099736112 0.3763369179 0.3775896683 0.0044093288 0.1440406795
[1201] 0.0076937698 0.0269577426 0.0017245703 0.0469364127 0.1083138030
[1206] 0.3935411058 0.0017529442 0.0148865592 0.2591624253 0.3892026332
[1211] 0.0063832579 0.0566840257 0.0198657882 0.3439166763 0.1086512116
[1216] 0.3261562446 0.1563839381 0.2457323456 0.0287087145 0.1197324783
[1221] 0.2757088068 0.0448050204 0.1183351186 0.0548432583 0.0050258760
[1226] 0.2111592332 0.0478755505 0.2977150667 0.1116004130 0.3475852972
[1231] 0.3100399133 0.4096640036 0.1498570469 0.1429556229 0.3804943265
[1236] 0.3076585809 0.0967332109 0.2170567436 0.0221135283 0.0777632461
[1241] 0.0797336573 0.3368907488 0.3463797232 0.4060273128 0.0011922026
[1246] 0.0248345020 0.0561839704 0.0642457955 0.0194057849 0.0195564129
[1251] 0.1313887456 0.3117717491 0.0581039602 0.2861968181 0.0036394968
[1256] 0.0012528456 0.1764012218 0.1822331884 0.0904241112 0.1491311802
[1261] 0.0885702981 0.2999249060 0.0377077978 0.0196218486 0.0835113376
[1266] 0.3506032570 0.2012464349 0.1792829481 0.3624283058 0.2691384382
[1271] 0.0727986445 0.0150058294 0.0017512857 0.0016598925 0.0023241085
[1276] 0.2246984027 0.1666710960 0.2008892518 0.0250267686 0.0037337811
[1281] 0.3610446919 0.2704520674 0.0147357094 0.1216758952 0.2956048035
[1286] 0.0062797306 0.3996815377 0.0314146658 0.0159070816 0.0119770237
[1291] 0.3736560007 0.1091956652 0.0197171662 0.3974053005 0.3685102550
[1296] 0.3045059388 0.0016882240 0.1594945426 0.0606173763 0.0333481257
[1301] 0.4052794624 0.1995303618 0.2638972492 0.0697437338 0.0505217074
[1306] 0.0353517782 0.0026004550 0.0062372790 0.1646661135 0.2273922402
[1311] 0.1214024028 0.0069539919 0.0347401409 0.0783076250 0.0045287450
[1316] 0.0081251912 0.1815840707 0.1669188878 0.0079223574 0.0078864255
[1321] 0.0114290986 0.4051994498 0.2017509088 0.2522870845 0.2947319997
[1326] 0.0258695320 0.1347520635 0.0539195181 0.0058165325 0.2052495892
[1331] 0.3641690261 0.0182989926 0.1145909074 0.2599019672 0.0014339568
[1336] 0.1470500381 0.2794095727 0.1928140806 0.2703761334 0.3592630210
[1341] 0.2235427690 0.1051913173 0.0541003447 0.0782416172 0.0952537631
[1346] 0.0414138218 0.1523027980 0.0067124275 0.0321926840 0.0071997839
[1351] 0.3269761546 0.0204673340 0.3977423925 0.3776311644 0.1960203809
[1356] 0.1238119067 0.2151017447 0.0355975518 0.0108844323 0.1187617928
[1361] 0.0180426418 0.0698949986 0.1369711649 0.2517750022 0.1297583482
[1366] 0.1522486147 0.0405808188 0.2976413433 0.2756892377 0.0920096672
[1371] 0.2533963399 0.0039297138 0.0186612058 0.3007352863 0.1701505235
[1376] 0.2234699149 0.1752564132 0.0368001991 0.0611665121 0.2611110553
[1381] 0.0332454486 0.2277005254 0.0396057202 0.3048535366 0.3324612481
[1386] 0.0102107051 0.2253488599 0.3508801622 0.2497819528 0.1473699122
[1391] 0.0115722074 0.0255876793 0.0106018567 0.0993158665 0.1730395611
[1396] 0.2623619580 0.3202892823 0.0996541811 0.2155454226 0.3515284177
[1401] 0.0015193842 0.0302138372 0.2876873734 0.0164426380 0.0115527483
[1406] 0.3697037952 0.0877248890 0.3208927323 0.0241289406 0.0466193967
[1411] 0.1665795910 0.2841731327 0.0578741745 0.0948946393 0.0340062857
[1416] 0.0581546193 0.4026494563 0.2416311702 0.2777844108 0.0135107249
[1421] 0.3892687604 0.2261842222 0.1719473489 0.2947018749 0.3174364947
[1426] 0.0747694512 0.3000316918 0.0803839420 0.0068743582 0.1079344229
[1431] 0.0937398617 0.0628659821 0.0625018001 0.3463393547 0.1186457719
[1436] 0.3995847508 0.3035677887 0.1346543414 0.1418970820 0.1649914166
[1441] 0.2426618417 0.3539895703 0.0611673330 0.0913005348 0.1243611832
[1446] 0.1739605275 0.0546387651 0.2828633196 0.0502677572 0.0111949775
[1451] 0.0562843712 0.0377693144 0.2823171407 0.1734681769 0.0921131796
[1456] 0.1433310809 0.0131237729 0.3857970578 0.0017313889 0.0064871715
[1461] 0.0004564005 0.0052169467 0.0551527073 0.2902347486 0.3543334186
[1466] 0.3400206058 0.1489750376 0.3347140768 0.0170055640 0.3439620298
[1471] 0.1592786846 0.3987455422 0.2881249309 0.0731724002 0.2059461705
[1476] 0.3847921223 0.1356149634 0.3755303241 0.3586909278 0.2984258653
[1481] 0.2202224526 0.0024696808 0.2726989222 0.0097669058 0.1094650584
[1486] 0.2294725216 0.1999888310 0.0080133268 0.0094174547 0.0094838398
[1491] 0.0087661549 0.2224282397 0.2873618346 0.1191557289 0.1169587504
[1496] 0.0407383300 0.2985112654 0.1252960971 0.1228738387 0.0114435928
[1501] 0.1366056734 0.3549076792 0.0814766220 0.1612758494 0.1335230830
[1506] 0.2988770352 0.4023735510 0.2522310453 0.0028987717 0.2764415920
[1511] 0.0063017923 0.3184379048 0.0267414186 0.1674065378 0.0089862379
[1516] 0.0546765186 0.1770832676 0.0509597833 0.2040570795 0.3755472296
[1521] 0.0173888013 0.1754361109 0.0926803260 0.1140525993 0.1216950396
[1526] 0.1245695376 0.3025194298 0.0835477859 0.0217459831 0.2633969428
[1531] 0.1592465594 0.0162247332 0.0082396931 0.1359864366 0.0102106757
[1536] 0.0234597184 0.0598646926 0.1677899105 0.0228037257 0.0413960098
[1541] 0.0032202861 0.1918087293 0.0059491053 0.0035431691 0.2649957557
[1546] 0.0067904637 0.0129379360 0.0430064990 0.0235244224 0.1351848786
[1551] 0.3135837331 0.3187643688 0.1574470815 0.3541277993 0.0096639545
[1556] 0.2079712105 0.3568699445 0.3148500408 0.2388630961 0.0118690748
[1561] 0.0650962543 0.0119500700 0.0518788702 0.0639454331 0.0281307232
[1566] 0.0529606263 0.0040363082 0.0073916556 0.0353430986 0.2494574789
[1571] 0.1858028701 0.2714572604 0.1124542605 0.0064665794 0.2778474190
[1576] 0.0005311531 0.3873463528 0.3830029177 0.0907722359 0.0021663861
[1581] 0.3223412985 0.0061402176 0.0345349627 0.3585635053 0.4071935240
[1586] 0.1963332850 0.0260853973 0.0009455519 0.1577588908 0.3398449629
[1591] 0.2421227351 0.0323223815 0.0124184940 0.2457957233 0.0353605775
[1596] 0.0129606194 0.2973277050 0.2256607021 0.0701385006 0.0697954034
[1601] 0.1474336579 0.1672184424 0.1296108311 0.3035974402 0.1299660638
[1606] 0.0146781213 0.1335525224 0.0941211961 0.1099004813 0.0196153563
[1611] 0.0169455311 0.0555487107 0.3530662608 0.1898735035 0.0975139564
[1616] 0.0169280758 0.1129485747 0.2799659603 0.2313913059 0.1166289694
[1621] 0.1512072131 0.2191015988 0.0649547814 0.3175365017 0.0952361013
[1626] 0.0327159424 0.2594038543 0.0369159098 0.2199132950 0.2202861369
[1631] 0.2654687128 0.0077049552 0.3417894490 0.0478856886 0.3100975896
[1636] 0.1061282530 0.1952729349 0.0894161353 0.0131409360 0.1679409090
[1641] 0.1794441289 0.3460499424 0.0051128872 0.2572606697 0.0154579151
[1646] 0.1137128798 0.3190042210 0.0162880209 0.0869336326 0.3260284353
[1651] 0.2082594448 0.0778355288 0.2595165231 0.1967159911 0.1188552370
[1656] 0.2627580732 0.1801557563 0.0083710010 0.1370874073 0.0962482025
[1661] 0.1513513863 0.3629609055 0.3236986553 0.0543626336 0.0361738468
[1666] 0.0020993723 0.3777597131 0.3286621983 0.3436790216 0.0412949851
[1671] 0.0885335000 0.0155585864 0.0327380852 0.0746613487 0.0292348185
[1676] 0.1899123188 0.0140141843 0.0789816505 0.3933914704 0.0984838353
[1681] 0.0021566176 0.0325098833 0.2668409346 0.1054648540 0.4022916037
[1686] 0.1666577962 0.3914648897 0.0309073377 0.0038018284 0.1418739740
[1691] 0.3050942433 0.2654798321 0.1434420156 0.0413372375 0.3757512350
[1696] 0.2322405672 0.1802307101 0.3526655980 0.1830696467 0.0143786835
[1701] 0.3933286818 0.1822458194 0.0089039908 0.4010945646 0.0036005150
[1706] 0.1803475661 0.0185130460 0.2035080644 0.1681140862 0.1527354254
[1711] 0.3916902975 0.0668496483 0.2830095980 0.4006029670 0.3799546933
[1716] 0.2826161717 0.0776122917 0.1080632742 0.3323188160 0.0054118542
[1721] 0.2474951367 0.3593279714 0.0928946263 0.0252597892 0.3218178458
[1726] 0.2122531360 0.2260709494 0.1607413443 0.0062699785 0.0223238931
[1731] 0.2740462399 0.2901607886 0.3501731213 0.1048240808 0.2219171995
[1736] 0.2187142138 0.0055252642 0.1388879640 0.0031379177 0.0064103311
[1741] 0.1527985119 0.2188367233 0.0183861438 0.2072856610 0.1946863859
[1746] 0.2237306505 0.2836921354 0.3002877339 0.0118734824 0.0371629550
[1751] 0.1267975011 0.2311475979 0.3533442939 0.3392646157 0.0774734652
[1756] 0.0236340691 0.2743563750 0.0603051798 0.1007388854 0.1742515158
[1761] 0.0275551685 0.3696254265 0.0049258344 0.0992348952 0.2785990783
[1766] 0.4047949552 0.1721059739 0.2453698528 0.1679184834 0.1825277755
[1771] 0.0071526054 0.2593491234 0.1048818739 0.1938166201 0.1009333632
[1776] 0.3526660556 0.0157693694 0.0468926079 0.3380522758 0.0094386174
[1781] 0.3938001254 0.2677403221 0.1208762560 0.1216788045 0.1133688649
[1786] 0.3929434981 0.2971830346 0.0331567649 0.0131196992 0.2179554940
[1791] 0.0593603364 0.1537231983 0.2055822804 0.2049641352 0.0110953412
[1796] 0.1772202509 0.0594122413 0.2737662677 0.0114585653 0.0804482502
[1801] 0.4074294497 0.2771015635 0.2210267975 0.1145174795 0.0855824186
[1806] 0.0179540356 0.2481396606 0.0559379342 0.0153699445 0.1501490864
[1811] 0.1605698421 0.1459767812 0.1112649704 0.3454391042 0.0735799535
[1816] 0.0830595449 0.1508994034 0.0812750705 0.3947738837 0.0229746316
[1821] 0.0020422128 0.0090018710 0.2946153831 0.0109640491 0.2109629098
[1826] 0.0596479120 0.0978518428 0.0102725577 0.0088047366 0.2617473385
[1831] 0.0014253609 0.2476551040 0.0448713294 0.3430521325 0.0344589054
[1836] 0.0040532196 0.0194983352 0.1792519959 0.3721172705 0.2485936272
[1841] 0.1538529390 0.0183080180 0.1152260939 0.0072691470 0.1346782983
[1846] 0.3721232302 0.1788604445 0.0325302133 0.2573968341 0.2456643070
[1851] 0.1681964345 0.3051858734 0.0277718204 0.2837785135 0.1085799850
[1856] 0.2063490356 0.0144858172 0.0076332147 0.2339713136 0.3332820100
[1861] 0.1433375349 0.0265509437 0.0051985080 0.2712863429 0.1874343816
[1866] 0.0743776706 0.1060035376 0.0260208374 0.0903590023 0.3677910909
[1871] 0.0358003051 0.1833060062 0.0725737410 0.0250450696 0.2623423658
[1876] 0.0143899169 0.1905533210 0.0037614596 0.2078745982 0.0593433943
[1881] 0.2227631165 0.0381468161 0.0059552860 0.0078214469 0.0564615529
[1886] 0.1543037423 0.0247443881 0.0594892198 0.0079465565 0.1915903174
[1891] 0.0439450526 0.0026513479 0.0834251949 0.1230533754 0.0564536476
[1896] 0.0380395032 0.0257478315 0.0364160269 0.0552926706 0.1883726533
[1901] 0.0112469466 0.3143425684 0.1047800504 0.0356356852 0.2491534808
[1906] 0.3605260759 0.1735101684 0.3902282846 0.0285919982 0.0473996362
[1911] 0.1242188762 0.0452848310 0.1260569339 0.0383724908 0.3932395468
[1916] 0.2649013882 0.2447439439 0.2683075221 0.0133930385 0.0643266636
[1921] 0.0989674985 0.0409632079 0.2891325244 0.3383833508 0.1047592406
[1926] 0.0722187094 0.1155255586 0.1814923946 0.2700069347 0.0234309367
[1931] 0.2122848097 0.0242538522 0.1041819573 0.2814538432 0.0122823862
[1936] 0.1083713920 0.1556300326 0.0067204835 0.2022138790 0.2214546652
[1941] 0.0077379435 0.0038915908 0.0108840641 0.0495114482 0.0020598499
[1946] 0.3920239270 0.2235050774 0.1596260457 0.2135452916 0.3494741420
[1951] 0.1328391894 0.1059057547 0.0192571437 0.1387291126 0.1591927720
[1956] 0.0416156413 0.3779197771 0.1895072894 0.2550685847 0.0065288026
[1961] 0.2832662756 0.3759889129 0.0570329446 0.0087674481 0.2482000559
[1966] 0.1547040790 0.1343544930 0.0095520654 0.1817023572 0.3911768907
[1971] 0.2654319248 0.0126152905 0.2035920223 0.3019715125 0.0021476029
[1976] 0.0043815984 0.0569114713 0.3293790133 0.3939298748 0.3613340532
[1981] 0.3056166191 0.0118930369 0.1129677867 0.0027170754 0.0151620164
[1986] 0.3784861710 0.3535309012 0.1010505963 0.0913428001 0.0053119212
[1991] 0.0191984838 0.0538357868 0.0749132954 0.3200135407 0.0494291367
[1996] 0.0720552881 0.1640254774 0.0105949143 0.0324027805 0.0476977047
[2001] 0.3997289619 0.0171060247 0.0388336344 0.2262421931 0.1415403937
[2006] 0.0020150741 0.3890592123 0.1591790739 0.1992727331 0.1746298019
[2011] 0.2930179129 0.0844484988 0.1290964341 0.3355560178 0.1107771752
[2016] 0.1104019482 0.0803296794 0.0017492599 0.1517758438 0.0034385858
[2021] 0.0139525500 0.1178907196 0.1327716752 0.2615057663 0.0358547274
[2026] 0.0103301957 0.0265787178 0.0038184509 0.0078660523 0.2578431414
[2031] 0.2885749506 0.0249955576 0.1074831685 0.0107488044 0.1519866784
[2036] 0.3092759153 0.0363427430 0.1411421002 0.1136421942 0.0118601204
[2041] 0.1884907585 0.1003890051 0.2831340829 0.2735758082 0.2478515024
[2046] 0.1782970552 0.2808711265 0.2726471700 0.0347906782 0.1717812091
[2051] 0.0003251343 0.0949794037 0.0704803936 0.0051747751 0.0444436761
[2056] 0.3870445669 0.1549464144 0.3762121432 0.2607412992 0.0071677149
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[1121] 0.6519722862 0.1593915698 0.2461898198 0.5747714125 0.6519722862
[1126] 0.2013371670 0.2221716145 0.6641851916 1.0000000000 0.4086211558
[1131] 0.6641851916 0.2887158049 0.6519722862 0.1839638292 0.4086211558
[1136] 0.0115016273 0.2013371670 0.5021331782 0.0167279943 0.0833940604
[1141] 0.6641851916 0.3503741755 0.0115016273 1.0000000000 0.1839638292
[1146] 0.6641851916 0.8242112831 0.5021331782 0.5747714125 0.5747714125
[1151] 0.2815090174 0.8242112831 1.0000000000 0.5021331782 0.0483720064
[1156] 0.0115016273 0.5556161527 0.1505295015 0.0037848058 0.6641851916
[1161] 1.0000000000 0.2461898198 0.0248308272 0.0037848058 0.6519722862
[1166] 0.0005636721 0.0005636721 0.8242112831 0.5379115089 0.0274355258
[1171] 0.3768301284 0.5429955445 0.8242112831 0.8949505097 0.0151701559
[1176] 0.5379115089 0.2221716145 1.0000000000 1.0000000000 0.1505295015
[1181] 0.1593915698 0.0833940604 0.5556161527 0.6519722862 1.0000000000
[1186] 0.5556161527 0.0041267581 0.0339041623 0.0151701559 0.1505295015
[1191] 0.3768301284 0.6519722862 0.0483720064 1.0000000000 0.4086211558
[1196] 1.0000000000 1.0000000000 1.0000000000 0.0115016273 0.4086211558
[1201] 0.0151701559 0.0833940604 0.0030243748 0.1505295015 0.2887158049
[1206] 1.0000000000 0.0030243748 0.0339041623 0.6519722862 1.0000000000
[1211] 0.0115016273 0.1593915698 0.0648868346 1.0000000000 0.2887158049
[1216] 1.0000000000 0.4086211558 0.6519722862 0.0833940604 0.2887158049
[1221] 0.6641851916 0.1406905823 0.2887158049 0.1593915698 0.0115016273
[1226] 0.5747714125 0.1505295015 0.8035675583 0.2887158049 1.0000000000
[1231] 0.8242112831 1.0000000000 0.4086211558 0.3866423085 1.0000000000
[1236] 0.8242112831 0.2815090174 0.5747714125 0.0648868346 0.2013371670
[1241] 0.2221716145 1.0000000000 1.0000000000 1.0000000000 0.0021198129
[1246] 0.0648868346 0.1593915698 0.1839638292 0.0584647951 0.0584647951
[1251] 0.3503741755 0.8242112831 0.1593915698 0.6641851916 0.0074445629
[1256] 0.0021198129 0.5021331782 0.5021331782 0.2461898198 0.4086211558
[1261] 0.2461898198 0.8035675583 0.0901361322 0.0584647951 0.2221716145
[1266] 1.0000000000 0.5556161527 0.5021331782 1.0000000000 0.6641851916
[1271] 0.2013371670 0.0370807760 0.0030243748 0.0030243748 0.0041267581
[1276] 0.5747714125 0.4689528851 0.5556161527 0.0648868346 0.0074445629
[1281] 1.0000000000 0.6641851916 0.0339041623 0.3309163995 0.7714628892
[1286] 0.0115016273 1.0000000000 0.0833940604 0.0370807760 0.0248308272
[1291] 1.0000000000 0.2887158049 0.0584647951 1.0000000000 1.0000000000
[1296] 0.8035675583 0.0030243748 0.4086211558 0.1593915698 0.0833940604
[1301] 1.0000000000 0.5556161527 0.6519722862 0.2013371670 0.1505295015
[1306] 0.0901361322 0.0056375291 0.0115016273 0.4689528851 0.5747714125
[1311] 0.3309163995 0.0151701559 0.0901361322 0.2013371670 0.0115016273
[1316] 0.0167279943 0.5021331782 0.4689528851 0.0151701559 0.0151701559
[1321] 0.0248308272 1.0000000000 0.5556161527 0.6519722862 0.6641851916
[1326] 0.0648868346 0.3503741755 0.1593915698 0.0115016273 0.5556161527
[1331] 1.0000000000 0.0483720064 0.2887158049 0.6519722862 0.0030243748
[1336] 0.4086211558 0.6641851916 0.5429955445 0.6641851916 1.0000000000
[1341] 0.5747714125 0.2815090174 0.1593915698 0.2013371670 0.2815090174
[1346] 0.1319900003 0.4086211558 0.0118060774 0.0833940604 0.0151701559
[1351] 1.0000000000 0.0648868346 1.0000000000 1.0000000000 0.5556161527
[1356] 0.3309163995 0.5747714125 0.0901361322 0.0248308272 0.2887158049
[1361] 0.0483720064 0.2013371670 0.3503741755 0.6519722862 0.3503741755
[1366] 0.4086211558 0.1319900003 0.8035675583 0.6641851916 0.2461898198
[1371] 0.6519722862 0.0083852507 0.0584647951 0.8035675583 0.5021331782
[1376] 0.5747714125 0.5021331782 0.0901361322 0.1593915698 0.6519722862
[1381] 0.0833940604 0.5747714125 0.1319900003 0.8035675583 1.0000000000
[1386] 0.0248308272 0.5747714125 1.0000000000 0.6519722862 0.4086211558
[1391] 0.0248308272 0.0648868346 0.0248308272 0.2815090174 0.5021331782
[1396] 0.6519722862 1.0000000000 0.2815090174 0.5747714125 1.0000000000
[1401] 0.0030243748 0.0833940604 0.6641851916 0.0483720064 0.0248308272
[1406] 1.0000000000 0.2461898198 1.0000000000 0.0648868346 0.1505295015
[1411] 0.4689528851 0.6641851916 0.1593915698 0.2815090174 0.0833940604
[1416] 0.1593915698 1.0000000000 0.6519722862 0.6641851916 0.0339041623
[1421] 1.0000000000 0.5747714125 0.5021331782 0.6641851916 0.8242112831
[1426] 0.2013371670 0.8035675583 0.2221716145 0.0151701559 0.2887158049
[1431] 0.2461898198 0.1839638292 0.1839638292 1.0000000000 0.2887158049
[1436] 1.0000000000 0.8035675583 0.3503741755 0.3768301284 0.4689528851
[1441] 0.6519722862 1.0000000000 0.1593915698 0.2461898198 0.3309163995
[1446] 0.5021331782 0.1593915698 0.6641851916 0.1505295015 0.0248308272
[1451] 0.1593915698 0.0901361322 0.6641851916 0.5021331782 0.2461898198
[1456] 0.3866423085 0.0287845847 1.0000000000 0.0030243748 0.0115016273
[1461] 0.0005636721 0.0115016273 0.1593915698 0.6641851916 1.0000000000
[1466] 1.0000000000 0.4086211558 1.0000000000 0.0483720064 1.0000000000
[1471] 0.4086211558 1.0000000000 0.6641851916 0.2013371670 0.5556161527
[1476] 1.0000000000 0.3503741755 1.0000000000 1.0000000000 0.8035675583
[1481] 0.5747714125 0.0056375291 0.6641851916 0.0213866457 0.2887158049
[1486] 0.5747714125 0.5556161527 0.0151701559 0.0213866457 0.0213866457
[1491] 0.0194077366 0.5747714125 0.6641851916 0.2887158049 0.2887158049
[1496] 0.1319900003 0.8035675583 0.3309163995 0.3309163995 0.0248308272
[1501] 0.3503741755 1.0000000000 0.2221716145 0.4689528851 0.3503741755
[1506] 0.8035675583 1.0000000000 0.6519722862 0.0056375291 0.6641851916
[1511] 0.0115016273 0.9051464024 0.0833940604 0.4689528851 0.0194077366
[1516] 0.1593915698 0.5021331782 0.1505295015 0.5556161527 1.0000000000
[1521] 0.0483720064 0.5021331782 0.2461898198 0.2887158049 0.3309163995
[1526] 0.3309163995 0.8035675583 0.2221716145 0.0648868346 0.6519722862
[1531] 0.4086211558 0.0483720064 0.0167279943 0.3503741755 0.0248308272
[1536] 0.0648868346 0.1593915698 0.4689528851 0.0648868346 0.1319900003
[1541] 0.0074445629 0.5379115089 0.0115016273 0.0074445629 0.6519722862
[1546] 0.0151701559 0.0287845847 0.1406905823 0.0648868346 0.3503741755
[1551] 0.8242112831 0.9051464024 0.4086211558 1.0000000000 0.0213866457
[1556] 0.5556161527 1.0000000000 0.8242112831 0.6519722862 0.0248308272
[1561] 0.2013371670 0.0248308272 0.1517509921 0.1839638292 0.0833940604
[1566] 0.1593915698 0.0083852507 0.0151701559 0.0901361322 0.6519722862
[1571] 0.5155516417 0.6641851916 0.2887158049 0.0115016273 0.6641851916
[1576] 0.0007944127 1.0000000000 1.0000000000 0.2461898198 0.0037848058
[1581] 1.0000000000 0.0115016273 0.0833940604 1.0000000000 1.0000000000
[1586] 0.5556161527 0.0648868346 0.0018271448 0.4086211558 1.0000000000
[1591] 0.6519722862 0.0833940604 0.0287845847 0.6519722862 0.0901361322
[1596] 0.0287845847 0.8035675583 0.5747714125 0.2013371670 0.2013371670
[1601] 0.4086211558 0.4689528851 0.3503741755 0.8035675583 0.3503741755
[1606] 0.0339041623 0.3503741755 0.2815090174 0.2887158049 0.0584647951
[1611] 0.0483720064 0.1593915698 1.0000000000 0.5379115089 0.2815090174
[1616] 0.0483720064 0.2887158049 0.6641851916 0.6499269982 0.2887158049
[1621] 0.4086211558 0.5747714125 0.1839638292 0.8242112831 0.2815090174
[1626] 0.0833940604 0.6519722862 0.0901361322 0.5747714125 0.5747714125
[1631] 0.6519722862 0.0151701559 1.0000000000 0.1505295015 0.8242112831
[1636] 0.2815090174 0.5429955445 0.2461898198 0.0339041623 0.4689528851
[1641] 0.5021331782 1.0000000000 0.0115016273 0.6519722862 0.0370807760
[1646] 0.2887158049 0.9051464024 0.0483720064 0.2461898198 1.0000000000
[1651] 0.5556161527 0.2013371670 0.6519722862 0.5556161527 0.2887158049
[1656] 0.6519722862 0.5021331782 0.0194077366 0.3503741755 0.2815090174
[1661] 0.4086211558 1.0000000000 1.0000000000 0.1593915698 0.0901361322
[1666] 0.0037848058 1.0000000000 1.0000000000 1.0000000000 0.1319900003
[1671] 0.2461898198 0.0370807760 0.0833940604 0.2013371670 0.0833940604
[1676] 0.5379115089 0.0339041623 0.2013371670 1.0000000000 0.2815090174
[1681] 0.0037848058 0.0833940604 0.6641851916 0.2815090174 1.0000000000
[1686] 0.4689528851 1.0000000000 0.0833940604 0.0074445629 0.3768301284
[1691] 0.8035675583 0.6519722862 0.4086211558 0.1319900003 1.0000000000
[1696] 0.6499269982 0.5021331782 1.0000000000 0.5021331782 0.0339041623
[1701] 1.0000000000 0.5021331782 0.0194077366 1.0000000000 0.0074445629
[1706] 0.5021331782 0.0483720064 0.5556161527 0.4689528851 0.4086211558
[1711] 1.0000000000 0.2013371670 0.6641851916 1.0000000000 1.0000000000
[1716] 0.6641851916 0.2013371670 0.2887158049 1.0000000000 0.0115016273
[1721] 0.6519722862 1.0000000000 0.2461898198 0.0648868346 1.0000000000
[1726] 0.5747714125 0.5747714125 0.4689528851 0.0115016273 0.0648868346
[1731] 0.6641851916 0.6641851916 1.0000000000 0.2815090174 0.5747714125
[1736] 0.5747714125 0.0115016273 0.3768301284 0.0073254652 0.0115016273
[1741] 0.4086211558 0.5747714125 0.0483720064 0.5556161527 0.5429955445
[1746] 0.5747714125 0.6641851916 0.8035675583 0.0248308272 0.0901361322
[1751] 0.3503741755 0.6499269982 1.0000000000 1.0000000000 0.2013371670
[1756] 0.0648868346 0.6641851916 0.1593915698 0.2815090174 0.5021331782
[1761] 0.0833940604 1.0000000000 0.0115016273 0.2815090174 0.6641851916
[1766] 1.0000000000 0.5021331782 0.6519722862 0.4689528851 0.5021331782
[1771] 0.0151701559 0.6519722862 0.2815090174 0.5429955445 0.2815090174
[1776] 1.0000000000 0.0370807760 0.1505295015 1.0000000000 0.0213866457
[1781] 1.0000000000 0.6641851916 0.3309163995 0.3309163995 0.2887158049
[1786] 1.0000000000 0.8035675583 0.0833940604 0.0287845847 0.5747714125
[1791] 0.1593915698 0.4086211558 0.5556161527 0.5556161527 0.0248308272
[1796] 0.5021331782 0.1593915698 0.6641851916 0.0248308272 0.2221716145
[1801] 1.0000000000 0.6641851916 0.5747714125 0.2887158049 0.2461898198
[1806] 0.0483720064 0.6519722862 0.1593915698 0.0370807760 0.4086211558
[1811] 0.4689528851 0.4086211558 0.2887158049 1.0000000000 0.2013371670
[1816] 0.2221716145 0.4086211558 0.2221716145 1.0000000000 0.0648868346
[1821] 0.0037848058 0.0194077366 0.6641851916 0.0248308272 0.5747714125
[1826] 0.1593915698 0.2815090174 0.0248308272 0.0194077366 0.6519722862
[1831] 0.0030243748 0.6519722862 0.1406905823 1.0000000000 0.0833940604
[1836] 0.0083852507 0.0584647951 0.5021331782 1.0000000000 0.6519722862
[1841] 0.4086211558 0.0483720064 0.2887158049 0.0151701559 0.3503741755
[1846] 1.0000000000 0.5021331782 0.0833940604 0.6519722862 0.6519722862
[1851] 0.4689528851 0.8035675583 0.0833940604 0.6641851916 0.2887158049
[1856] 0.5556161527 0.0339041623 0.0151701559 0.6499269982 1.0000000000
[1861] 0.3866423085 0.0833940604 0.0115016273 0.6641851916 0.5155516417
[1866] 0.2013371670 0.2815090174 0.0648868346 0.2461898198 1.0000000000
[1871] 0.0901361322 0.5021331782 0.2013371670 0.0648868346 0.6519722862
[1876] 0.0339041623 0.5379115089 0.0074445629 0.5556161527 0.1593915698
[1881] 0.5747714125 0.0901361322 0.0115016273 0.0151701559 0.1593915698
[1886] 0.4086211558 0.0648868346 0.1593915698 0.0151701559 0.5379115089
[1891] 0.1406905823 0.0056375291 0.2221716145 0.3309163995 0.1593915698
[1896] 0.0901361322 0.0648868346 0.0901361322 0.1593915698 0.5155516417
[1901] 0.0248308272 0.8242112831 0.2815090174 0.0901361322 0.6519722862
[1906] 1.0000000000 0.5021331782 1.0000000000 0.0833940604 0.1505295015
[1911] 0.3309163995 0.1442894480 0.3503741755 0.1215066279 1.0000000000
[1916] 0.6519722862 0.6519722862 0.6641851916 0.0339041623 0.1839638292
[1921] 0.2815090174 0.1319900003 0.6641851916 1.0000000000 0.2815090174
[1926] 0.2013371670 0.2887158049 0.5021331782 0.6641851916 0.0648868346
[1931] 0.5747714125 0.0648868346 0.2815090174 0.6641851916 0.0274355258
[1936] 0.2887158049 0.4086211558 0.0118060774 0.5556161527 0.5747714125
[1941] 0.0151701559 0.0074445629 0.0248308272 0.1505295015 0.0037848058
[1946] 1.0000000000 0.5747714125 0.4086211558 0.5747714125 1.0000000000
[1951] 0.3503741755 0.2815090174 0.0584647951 0.3768301284 0.4086211558
[1956] 0.1319900003 1.0000000000 0.5379115089 0.6519722862 0.0115016273
[1961] 0.6641851916 1.0000000000 0.1593915698 0.0194077366 0.6519722862
[1966] 0.4086211558 0.3503741755 0.0213866457 0.5021331782 1.0000000000
[1971] 0.6519722862 0.0287845847 0.5556161527 0.8035675583 0.0037848058
[1976] 0.0115016273 0.1593915698 1.0000000000 1.0000000000 1.0000000000
[1981] 0.8035675583 0.0248308272 0.2887158049 0.0056375291 0.0370807760
[1986] 1.0000000000 1.0000000000 0.2815090174 0.2461898198 0.0115016273
[1991] 0.0584647951 0.1593915698 0.2013371670 1.0000000000 0.1505295015
[1996] 0.2013371670 0.4689528851 0.0248308272 0.0833940604 0.1505295015
[2001] 1.0000000000 0.0483720064 0.1215066279 0.5747714125 0.3768301284
[2006] 0.0037848058 1.0000000000 0.4086211558 0.5556161527 0.5021331782
[2011] 0.6641851916 0.2221716145 0.3503741755 1.0000000000 0.2887158049
[2016] 0.2887158049 0.2221716145 0.0030243748 0.4086211558 0.0074445629
[2021] 0.0339041623 0.2887158049 0.3503741755 0.6519722862 0.0901361322
[2026] 0.0248308272 0.0833940604 0.0074445629 0.0151701559 0.6519722862
[2031] 0.6641851916 0.0648868346 0.2887158049 0.0248308272 0.4086211558
[2036] 0.8242112831 0.0901361322 0.3768301284 0.2887158049 0.0248308272
[2041] 0.5155516417 0.2815090174 0.6641851916 0.6641851916 0.6519722862
[2046] 0.5021331782 0.6641851916 0.6641851916 0.0901361322 0.5021331782
[2051] 0.0005636721 0.2815090174 0.2013371670 0.0115016273 0.1406905823
[2056] 1.0000000000 0.4086211558 1.0000000000 0.6519722862 0.0151701559
[2061] 0.3309163995 0.2887158049 0.1593915698 0.0115016273 0.3309163995
[2066] 0.0151701559 0.0115016273 0.2013371670 0.5556161527 0.5155516417
[2071] 0.6499269982 0.6641851916 0.1593915698 0.0483720064 0.0648868346
[2076] 0.2013371670 0.3768301284 0.5747714125 0.1593915698 0.2221716145
[2081] 0.2815090174 0.2815090174 0.2815090174 0.4086211558 0.0056375291
[2086] 0.0005636721 0.6519722862 0.1839638292 0.0339041623 0.4086211558
[2091] 1.0000000000 0.6519722862 1.0000000000 0.4689528851 0.0339041623
[2096] 0.0483720064 1.0000000000 0.1593915698 0.0370807760 0.2461898198
[2101] 0.0018763129 0.2815090174 0.1593915698 0.6641851916 1.0000000000
[2106] 0.4689528851 0.0115016273 1.0000000000 1.0000000000 0.0248308272
[2111] 0.4086211558 0.0018271448 0.1593915698 0.0151701559 0.4086211558
[2116] 1.0000000000 1.0000000000 0.2815090174 0.6519722862 0.1505295015
[2121] 0.5021331782 0.4086211558 0.8035675583 0.0833940604 1.0000000000
[2126] 1.0000000000 0.1505295015 0.3309163995 0.5556161527 0.2013371670
[2131] 0.0370807760 0.4689528851 0.5747714125 0.5747714125 0.4086211558
[2136] 0.1505295015 1.0000000000 0.2013371670 0.0194077366 1.0000000000
[2141] 0.1839638292 0.2013371670 0.5556161527 0.0018271448 0.0339041623
[2146] 0.0115016273 1.0000000000 0.2815090174 0.0115016273 0.6519722862
[2151] 0.0118060774 0.2221716145 0.5155516417 0.0151701559 0.6519722862
[2156] 0.0370807760 0.0648868346 0.2221716145 0.0274355258 0.0483720064
[2161] 0.0194077366 0.5747714125 0.0901361322 1.0000000000 0.5155516417
[2166] 0.2815090174 0.6641851916 0.5155516417 0.0056375291 1.0000000000
[2171] 0.4689528851 1.0000000000 0.5556161527 0.6519722862 1.0000000000
[2176] 0.8242112831 0.8242112831 1.0000000000 0.3503741755 0.6519722862
[2181] 0.0648868346 0.0648868346 0.5429955445 1.0000000000 1.0000000000
[2186] 0.6519722862 0.5379115089 0.0248308272 0.2815090174 0.2221716145
[2191] 0.3503741755 0.6519722862 0.0151701559 0.6519722862 1.0000000000
[2196] 1.0000000000 0.0833940604 0.5747714125 0.6519722862 0.0833940604
[2201] 0.0370807760 1.0000000000 0.2013371670 0.6641851916 0.0074445629
[2206] 0.5021331782 0.5747714125 0.4086211558 0.3503741755 0.2461898198
[2211] 0.2013371670 0.2013371670 1.0000000000 0.8035675583 0.5379115089
[2216] 0.0041267581 0.4086211558 0.3309163995 0.0115016273 0.1517509921
[2221] 0.0287845847 0.0901361322 0.3768301284 0.6641851916 0.5021331782
[2226] 0.0274355258 0.1839638292 0.0901361322 0.0115016273 0.0274355258
[2231] 0.0339041623 0.6641851916 0.4689528851 0.8242112831 0.6499269982
[2236] 0.5747714125 0.2461898198 0.3768301284 1.0000000000 0.5155516417
[2241] 0.0833940604 0.0115016273 0.2815090174 0.4689528851 0.5747714125
[2246] 0.0030243748 0.0037848058 0.8242112831 0.0339041623 0.1505295015
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[3381] 0.0339041623 0.1505295015 0.6519722862 0.6499269982 0.1319900003
[3386] 0.8242112831 1.0000000000 1.0000000000 0.0151701559 0.5021331782
[3391] 0.5747714125 0.5429955445 0.2887158049 0.1839638292 0.3503741755
[3396] 1.0000000000 1.0000000000 0.0274355258 0.2013371670 0.4086211558
[3401] 0.2013371670 0.5021331782 1.0000000000 0.0833940604 0.6519722862
[3406] 1.0000000000 0.1406905823 0.0483720064 0.6641851916 0.3768301284
[3411] 0.6519722862 1.0000000000 0.5021331782 0.0833940604 0.4086211558
[3416] 0.2887158049 0.6641851916 0.5021331782 0.0483720064 1.0000000000
[3421] 1.0000000000 0.9051464024 0.0018763129 0.5556161527 0.4086211558
[3426] 0.2221716145 1.0000000000 0.5379115089 0.6519722862 0.0901361322
[3431] 0.6519722862 0.1593915698 0.0339041623 0.8035675583 1.0000000000
[3436] 0.5379115089 0.0833940604 0.2461898198 1.0000000000 0.4689528851
[3441] 1.0000000000 0.6519722862 0.0115016273 0.5021331782 0.6519722862
[3446] 0.2013371670 0.1505295015 1.0000000000 0.6641851916 0.2013371670
[3451] 0.6641851916 0.5155516417 0.1505295015 0.2461898198 0.4086211558
[3456] 0.3503741755 0.6519722862 0.5021331782 1.0000000000 0.1505295015
[3461] 0.3768301284 1.0000000000 0.5747714125 0.5379115089 1.0000000000
[3466] 1.0000000000 0.0648868346 0.0339041623 0.8035675583 0.0151701559
[3471] 0.6519722862 0.6641851916 0.1505295015 0.0115016273 0.2461898198
[3476] 0.2815090174 0.6499269982 0.1839638292 0.2887158049 0.4086211558
[3481] 0.2013371670 0.0248308272 0.0648868346 0.1505295015 0.8035675583
[3486] 0.7714628892 0.0483720064 0.6641851916 0.4689528851 0.6641851916
[3491] 0.2887158049 0.5747714125 1.0000000000 0.6641851916 1.0000000000
[3496] 0.2221716145 0.8242112831 0.5747714125 0.1319900003 0.6641851916
[3501] 0.3768301284 0.8035675583 0.0248308272 0.6641851916 0.0056375291
[3506] 0.0083852507 0.8242112831 0.2221716145 0.2887158049 1.0000000000
[3511] 0.5155516417 0.5747714125 0.4689528851 0.2461898198 0.0339041623
[3516] 0.3503741755 0.0287845847 0.6641851916 0.4086211558 1.0000000000
[3521] 0.0648868346 0.7714628892 0.5747714125 0.3309163995 1.0000000000
[3526] 1.0000000000 0.0339041623 0.2461898198 0.2013371670 0.0151701559
[3531] 0.6519722862 0.2221716145 0.0901361322 0.8242112831 0.2013371670
[3536] 0.3309163995 1.0000000000 0.0287845847 1.0000000000 0.5021331782
[3541] 0.2013371670 0.6519722862 0.6641851916 0.8035675583 0.0194077366
[3546] 0.0833940604 0.0483720064 0.1505295015 0.6519722862 0.6519722862
[3551] 1.0000000000 1.0000000000 0.0074445629 0.1593915698 0.5429955445
[3556] 0.0115016273 0.0833940604 0.3503741755 0.5429955445 0.2461898198
[3561] 0.5747714125 1.0000000000 0.6519722862 0.5747714125 0.1593915698
[3566] 1.0000000000 0.2887158049 0.5429955445 0.8035675583 1.0000000000
[3571] 0.0833940604 0.5747714125 0.6519722862 1.0000000000 0.6519722862
[3576] 0.1505295015 1.0000000000 0.0115016273 0.0021198129 0.5747714125
[3581] 0.0287845847 0.6641851916 1.0000000000 0.0370807760 0.4086211558
[3586] 0.2887158049 0.0648868346 0.3503741755 0.5021331782 0.3503741755
[3591] 0.2221716145 0.5021331782 1.0000000000 0.0101691962 0.1215066279
[3596] 0.4086211558 1.0000000000 1.0000000000 0.2815090174 0.5556161527
[3601] 0.5747714125 0.6641851916 0.5747714125 0.2013371670 1.0000000000
[3606] 0.6519722862 0.3503741755 0.0287845847 1.0000000000 0.6519722862
[3611] 1.0000000000 0.2887158049 1.0000000000 0.6519722862 0.2887158049
[3616] 0.6519722862 0.5379115089 0.1593915698 0.5747714125 0.0194077366
[3621] 0.6519722862 0.6519722862 0.2013371670 1.0000000000 0.8242112831
[3626] 0.2887158049 0.8035675583 0.6641851916 0.2887158049 0.2013371670
[3631] 0.5021331782 0.0151701559 0.5747714125 1.0000000000 0.5556161527
[3636] 0.6519722862 0.2461898198 1.0000000000 0.6519722862 0.4086211558
[3641] 1.0000000000 0.6641851916 0.6641851916 0.3503741755 0.0648868346
[3646] 0.1839638292 0.2815090174 0.5747714125 0.6519722862 0.4086211558
[3651] 0.0833940604 0.0901361322 0.1593915698 0.1406905823 0.0248308272
[3656] 0.6641851916 0.2815090174 0.5747714125 0.0648868346 0.6519722862
[3661] 0.2013371670 0.6519722862 0.5747714125 0.2461898198 0.0483720064
[3666] 0.4086211558 0.0901361322 0.8035675583 0.6519722862 0.6519722862
[3671] 1.0000000000 0.0167279943 0.2887158049 0.2013371670 0.1505295015
[3676] 0.2815090174 0.5379115089 0.6641851916 0.8242112831 0.6641851916
[3681] 0.5155516417 0.2013371670 1.0000000000 0.5747714125 0.0274355258
[3686] 0.0339041623 0.1406905823 1.0000000000 0.2815090174 0.1517509921
[3691] 0.3503741755 0.6641851916 0.2013371670 0.0030243748 0.2887158049
[3696] 0.5155516417 0.3309163995 0.0833940604 0.0483720064 0.8035675583
[3701] 1.0000000000 0.2887158049 0.1593915698 0.5747714125 0.0648868346
[3706] 0.0115016273 0.5429955445 0.2013371670 0.3503741755 0.0370807760
[3711] 0.6519722862 0.2887158049 0.2013371670 0.0018271448 0.5747714125
[3716] 0.2013371670 0.6499269982 0.3503741755 0.5155516417 0.5747714125
[3721] 0.0833940604 0.3309163995 0.0483720064 0.0115016273 0.1505295015
[3726] 0.5556161527 0.0056375291 0.5379115089 1.0000000000 1.0000000000
[3731] 1.0000000000 0.5556161527 0.1839638292 0.0370807760 0.6519722862
[3736] 0.2461898198 1.0000000000 0.2013371670 0.2221716145 0.2815090174
[3741] 0.5021331782 0.0833940604 1.0000000000 1.0000000000 0.5747714125
[3746] 1.0000000000 0.0833940604 0.2013371670 0.1505295015 0.0648868346
[3751] 0.2887158049 0.8242112831 0.1839638292 1.0000000000 0.8035675583
[3756] 0.5747714125 0.0248308272 0.6519722862 0.5429955445 0.5747714125
[3761] 1.0000000000 0.0833940604 0.4086211558 0.2887158049 1.0000000000
[3766] 0.0833940604 0.2815090174 0.2461898198 0.1406905823 1.0000000000
[3771] 0.2887158049 0.5747714125 1.0000000000 0.5747714125 0.2221716145
[3776] 0.0483720064 0.2013371670 0.6519722862 1.0000000000 0.0648868346
[3781] 0.1517509921 0.5747714125 0.0483720064 0.0151701559 0.5556161527
[3786] 1.0000000000 0.3768301284 0.0648868346 0.0901361322 0.4086211558
[3791] 1.0000000000 0.0287845847 0.2815090174 0.1319900003 0.3503741755
[3796] 0.1406905823 0.0901361322 0.6499269982 0.3866423085 0.5556161527
[3801] 0.0833940604 0.8035675583 0.4086211558 0.0370807760 0.0030243748
[3806] 0.0115016273 0.3503741755 0.5021331782 0.0248308272 0.3503741755
[3811] 0.2461898198 0.6641851916 0.1517509921 0.0833940604 0.0194077366
[3816] 0.2887158049 0.6519722862 0.1319900003 0.0833940604 0.6641851916
[3821] 0.5747714125 0.0483720064 0.5155516417 1.0000000000 0.1505295015
[3826] 0.3503741755 0.1442894480 0.5021331782 0.0648868346 1.0000000000
[3831] 0.0648868346 0.1319900003 0.8242112831 1.0000000000 0.6499269982
[3836] 0.5747714125 0.6519722862 1.0000000000 0.5747714125 0.5429955445
[3841] 0.0194077366 0.0115016273 0.0074445629 0.2221716145 0.2221716145
[3846] 0.0115016273 0.1406905823 0.0648868346 0.0015908284 0.1593915698
[3851] 0.0248308272 0.0056375291 0.0248308272 0.0648868346 0.1505295015
[3856] 0.2013371670 0.6641851916 1.0000000000 1.0000000000 0.5021331782
[3861] 0.3503741755 0.2887158049 0.0901361322 0.1839638292 0.0118060774
[3866] 1.0000000000 0.0074445629 0.0073254652 1.0000000000 0.1505295015
[3871] 0.5155516417 1.0000000000 0.0339041623 1.0000000000 0.5155516417
[3876] 0.4689528851 0.5747714125 0.5747714125 0.0339041623 1.0000000000
[3881] 0.3503741755 0.3768301284 0.2013371670 0.5021331782 0.7714628892
[3886] 1.0000000000 0.3866423085 0.0194077366 1.0000000000 0.6641851916
[3891] 0.2815090174 0.2013371670 1.0000000000 1.0000000000 1.0000000000
[3896] 0.6641851916 0.6519722862 0.5747714125 0.0483720064 0.6519722862
[3901] 0.0648868346 0.3503741755 0.3503741755 0.6519722862 0.2461898198
[3906] 0.0833940604 0.0018271448 0.2461898198 0.4086211558 0.7714628892
[3911] 0.8242112831 1.0000000000 0.2887158049 0.4689528851 1.0000000000
[3916] 0.6641851916 0.6641851916 0.5556161527 0.4086211558 0.0339041623
[3921] 0.0833940604 0.0901361322 0.0115016273 0.2887158049 1.0000000000
[3926] 0.4086211558 0.2461898198 0.2815090174 0.0648868346 0.6641851916
[3931] 0.5747714125 0.5021331782 0.5556161527 0.1839638292 1.0000000000
[3936] 0.1406905823 0.0021198129 0.0833940604 0.0584647951 0.3768301284
[3941] 0.6641851916 0.1319900003 0.4086211558 0.8242112831 1.0000000000
[3946] 0.0901361322 0.0648868346 0.8035675583 0.6519722862 0.3503741755
[3951] 0.3503741755 0.5747714125 0.1406905823 0.5021331782 0.0833940604
[3956] 0.2013371670 0.2887158049 0.2461898198 0.5556161527 0.0339041623
[3961] 0.6519722862 0.0018271448 0.6641851916 0.0021198129 0.2221716145
[3966] 0.0213866457 0.6519722862 0.3768301284 0.6519722862 0.4086211558
[3971] 0.5747714125 0.5747714125 0.2887158049 0.0833940604 0.1839638292
[3976] 0.8035675583 0.1593915698 0.2461898198 0.3503741755 0.4086211558
[3981] 0.5747714125 0.5021331782 0.1593915698 0.0901361322 0.5747714125
[3986] 0.3768301284 0.6641851916 1.0000000000 0.1593915698 0.0248308272
[3991] 1.0000000000 1.0000000000 0.0248308272 0.6641851916 0.2013371670
[3996] 0.0648868346 0.6519722862 0.0118060774 0.4689528851 0.6519722862
[4001] 0.6519722862 0.0833940604 0.6641851916 1.0000000000 0.0118060774
[4006] 0.0648868346 0.5021331782 0.8242112831 1.0000000000 0.5556161527
[4011] 0.5556161527 0.0339041623 0.3309163995 0.0248308272 0.0074445629
[4016] 0.0833940604 0.3768301284 0.6641851916 0.0833940604 0.2013371670
[4021] 0.1593915698 0.6641851916 0.3768301284 0.1319900003 1.0000000000
[4026] 1.0000000000 0.8242112831 1.0000000000 0.0118060774 0.3309163995
[4031] 0.1593915698 0.6519722862 0.0648868346 0.6519722862 0.2887158049
[4036] 0.2221716145 0.5747714125 0.0287845847 0.1593915698 0.5747714125
[4041] 0.6641851916 0.4689528851 0.2815090174 0.2013371670 1.0000000000
[4046] 0.0901361322 0.0901361322 0.5429955445 1.0000000000 1.0000000000
[4051] 0.4086211558 0.6641851916 0.2013371670 0.6519722862 0.5021331782
[4056] 0.8035675583 0.6519722862 0.3503741755 0.1839638292 0.0901361322
[4061] 0.0833940604 1.0000000000 1.0000000000 0.6519722862 0.2815090174
[4066] 0.8035675583 1.0000000000 1.0000000000 0.6641851916 0.0248308272
[4071] 0.3309163995 0.0901361322 0.2815090174 0.8242112831 0.5747714125
[4076] 1.0000000000 1.0000000000 0.4086211558 0.6641851916 1.0000000000
[4081] 0.4689528851 0.8035675583 0.0115016273 0.0370807760 0.4086211558
[4086] 0.0584647951 0.0833940604 0.3503741755 1.0000000000 0.8035675583
[4091] 0.1406905823 0.8242112831 0.8242112831 0.0584647951 0.2221716145
[4096] 0.1593915698 0.0115016273 0.2887158049 0.5556161527 0.0901361322
[4101] 0.0213866457 1.0000000000 0.6641851916 1.0000000000 0.4689528851
[4106] 0.6519722862 0.0339041623 0.2221716145 0.0483720064 0.4086211558
[4111] 0.0648868346 1.0000000000 0.3503741755 0.4086211558 0.0648868346
[4116] 0.4689528851 0.5021331782 0.0648868346 0.5021331782 0.1505295015
[4121] 0.5747714125 0.6519722862 0.5021331782 0.2461898198 0.6641851916
[4126] 0.2887158049 0.6519722862 1.0000000000 1.0000000000 0.6641851916
[4131] 0.4086211558 0.3503741755 0.3309163995 0.3503741755 0.0115016273
[4136] 1.0000000000 0.0151701559 0.2815090174 1.0000000000 0.5021331782
[4141] 0.1593915698 0.4086211558 0.2461898198 0.0370807760 1.0000000000
[4146] 0.3503741755 0.2887158049 0.5747714125 1.0000000000 0.5556161527
[4151] 0.2815090174 0.2887158049 0.5747714125 0.5021331782 0.5021331782
[4156] 0.0194077366 0.0648868346 0.0901361322 0.2815090174 0.0648868346
[4161] 0.0648868346 0.0151701559 0.0151701559 0.2815090174 1.0000000000
[4166] 0.8035675583 1.0000000000 1.0000000000 0.6641851916 0.6519722862
[4171] 0.3503741755 0.5747714125 0.5747714125 0.3309163995 0.2815090174
[4176] 0.6641851916 0.4086211558 0.0287845847 0.6641851916 1.0000000000
[4181] 0.5747714125 1.0000000000 0.1505295015 0.1505295015 1.0000000000
[4186] 1.0000000000 1.0000000000 0.6499269982 0.6641851916 0.2013371670
[4191] 0.5747714125 0.2013371670 0.3503741755 0.6641851916 0.6499269982
[4196] 0.5021331782 1.0000000000 0.0833940604 0.6641851916 0.3309163995
[4201] 0.0037848058 0.0115016273 0.0115016273 0.1839638292 0.6519722862
[4206] 1.0000000000 0.6641851916 1.0000000000 0.2221716145 0.0213866457
[4211] 0.1215066279 0.0056375291 0.0151701559 0.6499269982 0.6641851916
[4216] 0.2887158049 0.1505295015 0.5155516417 0.4086211558 0.6641851916
[4221] 0.2221716145 0.8035675583 0.6519722862 1.0000000000 0.5556161527
[4226] 0.0056375291 0.0648868346 0.0151701559 0.0248308272 0.0483720064
[4231] 0.0483720064 0.0248308272 0.5747714125 0.0030243748 0.0030243748
[4236] 0.0901361322 1.0000000000 0.3503741755 0.1839638292 0.3503741755
[4241] 0.0901361322 0.5379115089 0.2815090174 0.0248308272 1.0000000000
[4246] 0.5556161527 0.0483720064 0.2013371670 0.0115016273 0.6519722862
[4251] 1.0000000000 0.0151701559 0.0833940604 1.0000000000 0.0248308272
[4256] 0.0151701559 0.1593915698 1.0000000000 0.2013371670 1.0000000000
[4261] 0.6519722862 0.1505295015 0.1593915698 0.0833940604 0.2013371670
[4266] 0.2815090174 0.4086211558 0.0115016273 0.0901361322 0.0248308272
[4271] 0.6641851916 1.0000000000 0.6519722862 1.0000000000 1.0000000000
[4276] 0.5155516417 0.2013371670 0.6641851916 0.0248308272 0.5747714125
[4281] 0.6641851916 0.2815090174 0.5556161527 0.6519722862 0.3503741755
[4286] 0.5556161527 0.0194077366 0.0648868346 0.2013371670
Step 1... determine cutoff point
Step 2... estimate parameters of null distribution and eta0
Step 3... compute p-values and estimate empirical PDF/CDF
Step 4... compute q-values and local fdr
Step 5... prepare for plotting

Step 1... determine cutoff point
Step 2... estimate parameters of null distribution and eta0
Step 3... compute p-values and estimate empirical PDF/CDF
Step 4... compute q-values and local fdr
Step 5... prepare for plotting

Step 1... determine cutoff point
Step 2... estimate parameters of null distribution and eta0
Step 3... compute p-values and estimate empirical PDF/CDF
Step 4... compute q-values and local fdr
Step 5... prepare for plotting
```

fdrtool documentation built on Nov. 14, 2021, 1:07 a.m.