cgd: Chronic Granulomatous Disease (CGD) Infection Data
In frailtyHL: Frailty Models via Hierarchical Likelihood

Description Usage Format References

The CGD data set in Fleming and Harrington (1991) is from a placebo-controlled randomized trial of gamma interferon in chronic granulomatous disease. In total, 128 patients from 13 hospitals were followed for about 1 year. The number of patients per hospital ranged from 4 to 26. Each patient may experience more than one infection. The survival times (times-to-event) are the times between recurrent CGD infections on each patient (i.e. gap times). Censoring occurred at the last observation for all patients, except one, who experienced a serious infection on the date he left the study.

1	data("cgd")

A data frame with 203 observations on the following 16 variables.

id: Patient number for 128 patients
center: Enrolling center number for 13 hospitals
random: Date of randomization
treat: Gamma-interferon treatment(rIFN-g) or placebo(Placebo)
sex: Sex of each patient(male, female)
age: Age of each patient at study entry, in years
height: Height of each patient at study entry, in cm
weight: Weight of each patient at study entry, in kg
inherit: Pattern of inheritance (autosomal recessive, X-linked)
steroids: Using corticosteroids at times of study centry(1=Yes, 0=No)
propylac: Using prophylactic antibiotics at time of study entry(1=Yes, 0=No)
hos.cat: A categorization of the hospital region into 4 groups
tstart: Start of each time interval
enum: Sequence number. For each patient, the infection records are in sequnce number order
tstop: End of each time interval
status: Censoring indicator (1=uncensored, 0=censored)

Fleming, T. R. and Harrington, D. R. (1991). Counting processes and survival analysis. Wiley: New York.

Therneasu, T. (2012). survival: survival analysis, including penalised likelihood. http://CRAN.Rproject. org/package=survival. R pakcage version 2.36-14.

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