funreg: Functional Regression for Irregularly Timed Data
Version 1.2
Performs functional regression, and some related
approaches, for intensive longitudinal data (see the book by Walls & Schafer,
2006, Models for Intensive Longitudinal Data, Oxford) when such data is not
necessarily observed on an equally spaced grid of times. The
approach generally follows the ideas of Goldsmith, Bobb, Crainiceanu,
Caffo, and Reich (2011) and the approach taken in their sample code, but
with some modifications to make it more feasible to use with long rather
than wide, non-rectangular longitudinal datasets with unequal and
potentially random measurement times. It also allows easy plotting of the
correlation between the smoothed covariate and the outcome as a function of
time, which can add additional insights on how to interpret a functional
regression. Additionally, it also provides several permutation tests for
the significance of the functional predictor. The heuristic interpretation
of ``time'' is used to describe the index of the functional predictor, but
the same methods can equally be used for another unidimensional continuous
index, such as space along a north-south axis. The development of this
package was part of a research project supported by Award R03 CA171809-01
from the National Cancer Institute and Award P50 DA010075 from the National
Institute on Drug Abuse. The content is solely the responsibility of the
authors and does not necessarily represent the official views of the
National Institute on Drug Abuse, the National Cancer Institute, or the
National Institutes of Health.