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grantham: Calculate the Grantham Distance
A minimal set of routines to calculate the Grantham distance <doi:10.1126/science.185.4154.862>. The Grantham distance attempts to provide a proxy for the evolutionary distance between two amino acids based on three key chemical properties: composition, polarity and molecular volume. In turn, evolutionary distance is used as a proxy for the impact of missense mutations. The higher the distance, the more deleterious the substitution is expected to be.
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Package details |
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| Author | Ramiro Magno [aut, cre] (<https://orcid.org/0000-0001-5226-3441>), Isabel Duarte [aut] (<https://orcid.org/0000-0003-0060-2936>), Ana-Teresa Maia [aut] (<https://orcid.org/0000-0002-0454-9207>), University of Algarve [fnd], CINTESIS [fnd], Pattern Institute [cph, fnd] |
| Maintainer | Ramiro Magno <rmagno@pattern.institute> |
| License | MIT + file LICENSE |
| Version | 0.1.2 |
| URL | https://www.pattern.institute/grantham/ https://github.com/patterninstitute/grantham |
| Package repository | View on CRAN |
| Installation |
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