grantham-package: grantham: Calculate the 'Grantham' Distance

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A minimal set of routines to calculate the 'Grantham' distance <doi:10.1126/science.185.4154.862>. The 'Grantham' distance attempts to provide a proxy for the evolutionary distance between two amino acids based on three key chemical properties: composition, polarity and molecular volume. In turn, evolutionary distance is used as a proxy for the impact of missense mutations. The higher the distance, the more deleterious the substitution is expected to be.


Maintainer: Ramiro Magno (ORCID)


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grantham documentation built on Jan. 7, 2022, 9:06 a.m.