gsDesign2: Group Sequential Design with Non-Constant Effect

The goal of 'gsDesign2' is to enable fixed or group sequential design under non-proportional hazards. To enable highly flexible enrollment, time-to-event and time-to-dropout assumptions, 'gsDesign2' offers piecewise constant enrollment, failure rates, and dropout rates for a stratified population. This package includes three methods for designs: average hazard ratio, weighted logrank tests in Yung and Liu (2019) <doi:10.1111/biom.13196>, and MaxCombo tests. Substantial flexibility on top of what is in the 'gsDesign' package is intended for selecting boundaries.

Package details

AuthorKeaven Anderson [aut], Yilong Zhang [aut], Yujie Zhao [aut, cre], Jianxiao Yang [aut], Nan Xiao [aut], Amin Shirazi [ctb], Ruixue Wang [ctb], Yi Cui [ctb], Ping Yang [ctb], Xin Tong Li [ctb], Chenxiang Li [ctb], Hiroaki Fukuda [ctb], Hongtao Zhang [ctb], Yalin Zhu [ctb], John Blischak [ctb], Dickson Wanjau [ctb], Merck & Co., Inc., Rahway, NJ, USA and its affiliates [cph]
MaintainerYujie Zhao <yujie.zhao@merck.com>
LicenseGPL-3
Version1.1.3
URL https://merck.github.io/gsDesign2/ https://github.com/Merck/gsDesign2
Package repositoryView on CRAN
Installation Install the latest version of this package by entering the following in R:
install.packages("gsDesign2")

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gsDesign2 documentation built on April 3, 2025, 9:39 p.m.