gsDesign2-package: gsDesign2: Group Sequential Design with Non-Constant Effect

In gsDesign2: Group Sequential Design with Non-Constant Effect

gsDesign2: Group Sequential Design with Non-Constant Effect

Description

The goal of 'gsDesign2' is to enable fixed or group sequential design under non-proportional hazards. To enable highly flexible enrollment, time-to-event and time-to-dropout assumptions, 'gsDesign2' offers piecewise constant enrollment, failure rates, and dropout rates for a stratified population. This package includes three methods for designs: average hazard ratio, weighted logrank tests in Yung and Liu (2019) \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1111/biom.13196")}, and MaxCombo tests. Substantial flexibility on top of what is in the 'gsDesign' package is intended for selecting boundaries.

Author(s)

Maintainer: Yujie Zhao [e-mail]

Authors:

• Keaven Anderson [e-mail]

• Yilong Zhang [e-mail]

• Jianxiao Yang [e-mail]

• Nan Xiao [e-mail]

Other contributors:

• Amin Shirazi [e-mail] [contributor]

• Ruixue Wang [e-mail] [contributor]

• Yi Cui [e-mail] [contributor]

• Ping Yang [e-mail] [contributor]

• Xin Tong Li [e-mail] [contributor]

• Chenxiang Li [e-mail] [contributor]

• Hiroaki Fukuda [e-mail] [contributor]

• Hongtao Zhang [e-mail] [contributor]

• Yalin Zhu [e-mail] [contributor]

• John Blischak [e-mail] [contributor]

• Dickson Wanjau [e-mail] [contributor]

• Merck & Co., Inc., Rahway, NJ, USA and its affiliates [copyright holder]

See Also

Useful links:

• https://merck.github.io/gsDesign2/

• https://github.com/Merck/gsDesign2

• Report bugs at https://github.com/Merck/gsDesign2/issues

gsDesign2 documentation built on April 3, 2025, 9:39 p.m.