conditional_A: Example conditional A matrix of hJAM

Description Usage Format References


Example conditional A matrix of hJAM




The conditional_A is the conditional estimates alpha matrix in the hJAM model: the association estimates between 210 SNPs and body mass index (BMI) and type 2 diabetes (T2D). The summary data was collected from GIANT consortium (n=339,224) and DIAGRAM+GERA+UKB (n=659316) for BMI and T2D, respectively. We converted it from marginal_A, using get_cond_A function in hJAM package.


1. Locke AE, Kahali B, Berndt SI, et al. Genetic studies of body mass index yield new insights for obesity biology. Nature 2015; 518: 197-206. 2. Xue A, Wu Y, Zhu Z, et al. Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes. Nat Commun 2018; 9: 2941.

hJAM documentation built on March 26, 2020, 8:13 p.m.