LRtox: Calculates likelihood of safety for single dose

In iAdapt: Two-Stage Adaptive Dose-Finding Clinical Trial Design

Description

Function LRtox() calculates the likelihood of safety for a single dose and designates whether to escalate to the next dose (safe) or stop dose escalation and move onto stage 2 (unsafe).

Usage

LRtox(coh.size, ndlt, p1, p2, K = 2)

Arguments

coh.size	cohort size (number of patients) per dose (Stage 1)
ndlt	number of observed DLTs
p1	toxicity under null (unsafe DLT rate). Values range from 0 - 1.
p2	toxicity under alternative (safe DLT rate). Values range from 0 - 1; p1 > p2
K	threshold for LR. Takes integer values: 1,2,...(recommended K=2)

Value

List object that gives the likelihood ratio of safety and indicates whether to escalate to the next highest dose level, or stop dose escalation and move onto stage 2.

Examples

LRtox(coh.size = 3, ndlt = 2, p1 = 0.40, p2 = 0.15, K = 2)
LRtox(coh.size = 3, ndlt = 1, p1 = 0.40, p2 = 0.15, K = 2)

iAdapt documentation built on Aug. 6, 2021, 9:08 a.m.