nTTP.indiv.sim: Simulate full trial (both stages) x times when using nTTP to...

In iAdapt: Two-Stage Adaptive Dose-Finding Clinical Trial Design

Description

Results are displayed in a matrix format, where each row represents one trial simulation

Usage

nTTP.indiv.sim(W, TOX, ntox, dose)

Arguments

W	matrix defining burden weight of each grade level for all toxicity types. The dimensions are ntox rows by 5 columns (for grades 0-4). See Ezzalfani et al. (2013) for details.
TOX	matrix array of toxicity probabilities. There should be ntox matrices. Each matrix represents one toxicity type, where probabilities of each toxicity grade are specified across each dose. Each matrix has the same dimensions: n rows, representing number of doses, and 5 columns (for grades 0-4). Probabilities across each dose (rows) must sum to 1. See Ezzalfani et al. (2013) for details.
ntox	number (integer) of different toxicity types
dose	number of doses to be tested (scalar)

Value

List of the following objects:

• sim.Y - estimated efficacy per each dose assignment

• sim.d - dose assignment for each patient in the trial

iAdapt documentation built on Aug. 6, 2021, 9:08 a.m.