rand.prob: Calculates randomization probabilities and dose allocation...

In iAdapt: Two-Stage Adaptive Dose-Finding Clinical Trial Design

Description

Function rand.prob() calculates the updated randomization probabilities based on observed efficacies up to that point. It also gives the dose allocation for the next enrolled patient based on these probabilities.

Usage

rand.prob(y.eff, d.safe)

Arguments

y.eff	vector of all efficacy outcomes for each dose allocation
d.safe	vector of dose assignment

Value

List object giving

• Rand.Prob - randomization probability for each safe dose (from stage 1)

• Next.Dose - the dose to enroll the next patient on

Examples

y.eff <- c(9, 1, 0, 34, 10, 27, 38, 42, 60, 75, 48, 62)
d.safe <- c(1, 1, 1, 2, 2, 2, 3, 3, 3, 4, 4, 4)
rand.prob(y.eff, d.safe)

iAdapt documentation built on Aug. 6, 2021, 9:08 a.m.