Description Objects from the Class Slots Methods See Also Examples
The ipdlme
class represents the fit of a linear mixed-effects model of individual patient data meta-analysis of multiple parallel group clinical trials, based on aggregate data estimation methods.
Objects can be created by calls of the
form new("ipdlme", ...)
or via the function
ipdlme
.
The class "ipdlme"
represents a linear mixed model to assess effect modification of multiple clinical trials and contains the slots:
fixef
:The vector of the population effect estimates.
ranef
:The matrix of the study-specific intercept and treatment random effects.
vcov.fixef
:The variance-covariance matrix for inference with the population effects.
vcov.ranef
:The variance-covariance matrix for inference with the study random effects.
sigma2
:Estimate of the residual variance.
VarCorr
:Covariance-variance matrix for bivariate normal random effects.
convergence.trace
:A list of the values of each of the effects and variance components at each iteration in the maximization algorith.
converged
:Logical value indicating whether the convergence criterion was met.
n.iter
:The total number of iterations used in the optimization algorithm.
max.iter
:The maximum number of iterations specified for the optimization algorithm.
tol
:The tolerance level on which the termination rule for convergence is based.
df
:The degrees of freedom of the model fit.
The following methods are extractors for the component that shares the method's name:
fixef
signature(object = "ipdlme")
ranef
signature(object = "ipdlme")
coef
signature(object = "ipdlme")
vcov
signature(object = "ipdlme")
Var
signature(object = "ipdlme")
sigma2
signature(object = "ipdlme")
vcov.fixef
signature(object = "ipdlme")
vcov.ranef
signature(object = "ipdlme")
convergence
signature(object = "ipdlme")
converged
signature(object = "ipdlme")
n.iter
signature(object = "ipdlme")
tol
signature(object = "ipdlme")
max.iter
signature(object = "ipdlme")
print
signature(x = "ipdlme")
: print information about
the fitted model.
show
signature(object = "ipdlme")
: Same as the
print
method.
confint
signature(object = "ipdlme",parm, level = 0.95, ...)
Returns the specified confidence interval for all the population parameters.
plot
signature(x = "ipdlme",y,...)
: Displays a forest plot of the study intercept and treatment effects with the option of user-defined labels for the studies.
summary
signature(object = "ipdlme")
:Summary table of standard error and Wald tests for the population effects. A list of the study random effects and estimates of the variance components are also displayed.
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