macula_rwe: Meta-analysis: 83 observational studies assessing the...

In jarbes: Just a Rather Bayesian Evidence Synthesis

Meta-analysis: 83 observational studies assessing the effectiveness of intravitreal therapy for diabetic maculaedema

Description

Meta-analysis of 83 studies comparing 12-month visual acuity change results in routine clinical practices of intravitreal therapy for diabetic maculaedema (DME) to the change in RCTs by pooling data published in the last decade on treated eyes of treatment effect from OS.

Format

A dataframe with 83 rows and 13 columns. Each row represents study results, the columns are:

therapy

Used Medication

author_year

Author and year.

eyes

Number of tested eyes.

TE

Mean Change in Visual Acuity after 12-Months. Where Visual Acuity is measured in VAR (Visual Acuity Rating) score

seTE

Standard Error of the Treatment Effect

lower_95pct_ci

Lower 95prc CI for TE

upper_95pct_ci

Upper 95prc CI for TE

number_of_patients_at_baseline

Number of Patients in Study at Baseline

mean_age

The mean age of patients per study

baseline_va

Mean Visual Acuity at Baseline. Where Visual Acuity is measured in VAR (Visual Acuity Rating) score

12_month_va

Mean Visual Acuity after 12 months. Where Visual Acuity is measured in VAR (Visual Acuity Rating) score

baseline_cst

Mean Central Subfield Thickness at Baseline

12_month_cst

Mean Central Subfield Thickness after 12 months

Source

Mehta H, Nguyen V, Barthelmes D, Pershing S, Chi GC, Dopart P, Gillies MC. Outcomes of Over 40,000 Eyes Treated for Diabetic Macula Edema in Routine Clinical Practice: A Systematic Review and Meta-analysis. Adv Ther. 2022 Dec;39(12):5376-5390. doi: 10.1007/s12325-022-02326-8. Epub 2022 Oct 15. PMID: 36241963; PMCID: PMC9618488.

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