Perform likelihood estimation and dynamic prediction under joint frailty-copula models for tumour progression and death in meta-analysis. A penalized likelihood is employed for estimating model parameters, where the baseline hazard functions are approximated by smoothing splines. The methods are applicable for meta-analytic data combining several studies. The methods can analyze data having information on both terminal event time (e.g., time-to-death) and non-terminal event time (e.g., time-to-tumour progression). See Emura et al. (2017) <doi:10.1177/0962280215604510> for likelihood estimation, and Emura et al. (2018) <doi:10.1177/0962280216688032> for dynamic prediction. Survival data from ovarian cancer patients are also available.
|Maintainer||Takeshi Emura <[email protected]>|
|Package repository||View on CRAN|
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