A mouse split-plot experiment with two treatments.
A data frame with 24 rows and 5 variables:
Mice were from one of six litters.
Male or Female.
VPA or saline (SAL).
MPEP or saline (SAL).
Six pregnant female mice were randomly assigned to receive an injection of valproic acid (n = 3) or saline (n = 3). The offspring of these mice (n = 24) were then randomly assigned to receive an injection of the glutamate receptor antagonist MPEP (n = 12) or saline (n = 12). There are two levels of randomisation: the pregnant females and their offspring.
This is a subset of the full data set from Mehta et al., which contained fourteen litters. The litters were selected to have an equal sample size across all conditions for illustrative purposes. The complete data can be found in the supplementary material of Lazic and Essioux (2013).
Mehta MV, Gandal MJ, Siegel SJ (2011). mGluR5-antagonist mediated reversal of elevated stereotyped, repetitive behaviors in the VPA model of autism. PLoS ONE 6(10):e26077.
Lazic SE, Essioux L (2013). Improving basic and translational science by accounting for litter-to-litter variation in animal models. BMC Neuroscience 14:37.
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