directpvalcombi: Direct p-value combination

In metaMA: Meta-Analysis for MicroArrays

Direct p-value combination

Description

Combines one sided p-values with the inverse normal method.

Usage

directpvalcombi(pvalonesided, nrep, BHth = 0.05)

Arguments

pvalonesided	List of vectors of one sided p-values to be combined.
nrep	Vector of numbers of replicates used in each study to calculate the previous one-sided p-values.
BHth	Benjamini Hochberg threshold. By default, the False Discovery Rate is controlled at 5%.

Value

List

DEindices	Indices of differentially expressed genes at the chosen Benjamini Hochberg threshold.
TestStatistic	Vector with test statistics for differential expression in the meta-analysis.

Note

One-sided p-values are required to avoid directional conflicts. Then a two-sided test is performed to find differentially expressed genes.

Author(s)

Guillemette Marot

References

Hedges, L. and Olkin, I. (1985). Statistical Methods for Meta-Analysis. Academic Press.

metaMA documentation built on April 12, 2022, 5:07 p.m.