Man pages for microsamplingDesign
Finding Optimal Microsampling Designs for Non-Compartmental Pharmacokinetic Analysis
| addSchemes | add user defined scheme to an existing 'SetOfSchemes-class'... |
| changeDevSettings | Function to overwrite default settings, print to console when... |
| checkConstraintsOk | test constraints well specified |
| check_scheme_exactNumberObsPerTimePoint | check the number of observations per time points is equal... |
| check_scheme_minObsPerTimePoint | check the mimimum observations per time points is above a... |
| check_subject_maxConsecSamples | check the maximum of consecutive samples per subject falls... |
| construct2CompModel | construct a 2 compartmental 'PkModel-class' by providing... |
| constructSetOfSchemes | construct user defined 'SetOfSchemes-class' |
| doAllSchemeChecks | check whether either a 1 subject or multiple subject... |
| estimatePopCurve | estimate population Pk curve from a scheme and pkData |
| extractByRank | extract a timepoint or Scheme choice by its rank |
| flagSchemesMeetingConstraints | internal function to check scheme constraints ( faster ) |
| flattenSetOfSchemes | Transform 3 way array to 2 way array |
| formatTimePoints | Format time points as a set |
| genMVN | Internal function to generate multivariate data via a... |
| get2ComptModelCurve | provides solution of two compartmental pharmacodynamic model... |
| getAllTimeOptions | generate all possible time options from eligible time points... |
| getCoeffVariationError | generic function to extract 'coeffVariationError' slot |
| getCombinationsWithMaxNRepetitions | get all combinations with a maximum number of repetitions |
| getConstraintsExample | get a minimal example of a constraint data frame |
| getCorrelationMatrix | generic function to extract the 'correlationMatrix'-slot |
| getData | generic function to extract the '.Data'-slot |
| getDevRankingSettings | function default ranking settings |
| getDosingInfo | generic function to extract 'dosingInfo'-slot |
| getExampleData | generate an mimimal example of a Pk data without a model |
| getExampleObjective | example objective function for 'rankObject' |
| getExampleParameters | get example parameters to use in 'pkOdeModel2Compartments'... |
| getExamplePkCurve | example of 1 pk curve to be used to test... |
| getExamplePkModel | get minimal example of 'PkModel-class' |
| getExamplePkModelRange | get minimal example of 'PkModelRange-class' |
| getExampleSetOfSchemes | get a minimal example of a set of schemes object |
| getExampleSetOfTimePoints | get a minimal example set of time points to test functions... |
| getExampleTimeData | generate example PkData object to be used in example... |
| getExampleTimeZones | working example time zone dataframe to use in examples |
| getIndividualParameters | sample subject specific parameters to input in... |
| getMMCurve | calculate Michealis-Menten relation between x and velocity... |
| getModelFunction | generic function to extract 'modelFunction' slot from... |
| getNames | generic function extract the names of an S4-object |
| getNSchemes | generic function to extract 'nSchemes'-slot |
| getNSubjects | generic function to extract 'nSubjects'-slot |
| getParameters | generic function to extract 'parameter'-slot |
| getPkData | simulate 'PkData-class' from 'PkModel-class' |
| getPkModel | generic function extract a 'PkModel-class' |
| getPkModelArticle | reproduce the example of the article of Helen Barnet et al. |
| getPkModels | Generate all possible 'PkModel-class' from... |
| getRanking | generic function to extract the 'ranking'-slot |
| getResultPerScheme | get a result of the criteria per scheme zero concentration at... |
| getSetOfSchemes | Generate a 'SetOfSchemes-class' object of speficified... |
| getSummaryRanks | internal function to rank by a summary function over criterio |
| getTimeChoicePerformance | estimate the distance between population average an average... |
| getTimePoints | generic function to extract 'timePoints'-slot |
| getTopNRanking | extract the top n rankings as numeric vector |
| grapes-ARC-grapes | All Row Combinations (ARC) function take all combination of... |
| oneCompartmentOralModel | solution of one compartmental oral administration model only... |
| pkCurveStat | calculate summary statistics from a pkCurve |
| PkData-class | An S4 object containing samples from a Pk model |
| PkModel-class | S4 class PkModel representing a pharmacokinetic model and its... |
| PkModelParent-class | virtual class, for testing 'PkModel-class' and... |
| PkModelRange-class | S4 class PkModel representing a pharmacokinetic model and its... |
| pkOdeModel2Compartments | Set of differential equations representing two compartmental... |
| plotAverageRat | plot plasma concentration for average individual (i.e average... |
| plotMMCurve | plot Michealis-Menten curve for either capacity dependent... |
| plotMMKinetics | plot MM kinetics of both absorption and clearance |
| plotObject | generic function to plot an object |
| rankBasedOnDirectory | internal function apply ranking per directory |
| rankObject | generic function to calulate a 'ranking'-slot |
| rankObjectWithRange | Rank a 'SetOfSchemes-class' or a 'SetOfTimePoints' object... |
| runMicrosamplingDesignApp | Run the PkPlotApp in a new tab in your browser |
| setCoeffVariationError | replace 'coeffVariationError'-slot |
| setCorrelationMatrix | replace 'correlationMatrix'-slot |
| setDosingInfo | replace 'dosingInfo'-slot |
| setModelToAverageRat | get a model with all variances to zero |
| SetOfSchemes-class | S4 class SetOfSchemes representing a set of designs with... |
| SetOfTimePoints-class | S4 class SetOfTimePoints representing a set of designs with... |
| setParameters | replace 'parameters'-slot |
| setRanking | replace 'ranking'-slot |
| setTimePoints | generic function to replace 'timePoints'-slot |
| subsetOnTimePoints | generic function to subset the 'timePoints'-slot and generate... |
| summary | function to summarize an object |
| summary-SetOfSchemes-method | summarize object |
