getMMCurve: calculate Michealis-Menten relation between x and velocity...

In microsamplingDesign: Finding Optimal Microsampling Designs for Non-Compartmental Pharmacokinetic Analysis

Description

calculate Michealis-Menten relation between x and velocity and rate

Usage

getMMCurve(x, Vmax, kappaMM, constantValue = NA)

Arguments

x	numeric vector, independent variable in Michaelis-Menten function representing a concentration or dose
Vmax	is the maximum rate ( x * Vmax / (kappaMM + x ) ) with increasing x
kappaMM	scalar representing Michaelis-Menten constant wich is the x at the rate reaches half of Vmax
constantValue	mumeric constant if not NULL , the rate equals x*constantValue with Vmax and kappaMM are ignored, defaults to NA

Value

data.frame given te relation between concentration and velocity and rate with columns

• x

• velocity wich is rate/concentration

• rate rate ( x * Vmax / (kappaMM + x )

• Vmax input value

• kappaMM input value

Examples

  getMMCurve( x = seq( 0 , 1 , 0.01 ) , Vmax = 5 , kappaMM = 0.3 )
  getMMCurve( x = seq( 0 , 3 , 0.01 ) , Vmax = 5 , kappaMM = 0.3 )
  getMMCurve( x = seq( 0 , 1 , 0.01 ) , Vmax = 5 , kappaMM = 0.3 , constantValue = 3 ) 

microsamplingDesign documentation built on Oct. 13, 2021, 5:10 p.m.