ad_data: Alzheimer's disease data

Description Details Value Source Examples

Description

Alzheimer's disease data

Details

Craig-Schapiro et al. (2011) describe a clinical study of 333 patients, including some with mild (but well-characterized) cognitive impairment as well as healthy individuals. CSF samples were taken from all subjects. The goal of the study was to determine if subjects in the early states of impairment could be differentiated from cognitively healthy individuals. Data collected on each subject included:

For these analyses, we have converted the scores to two classes: impaired and healthy. The goal of this analysis is to create classification models using the demographic and assay data to predict which patients have early stages of disease.

Value

ad_data

a tibble

Source

Kuhn, M., Johnson, K. (2013) Applied Predictive Modeling, Springer.

Craig-Schapiro R, Kuhn M, Xiong C, Pickering EH, Liu J, Misko TP, et al. (2011) Multiplexed Immunoassay Panel Identifies Novel CSF Biomarkers for Alzheimer's Disease Diagnosis and Prognosis. PLoS ONE 6(4): e18850.

Examples

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Example output

Classestbl_df,tbland 'data.frame':	333 obs. of  131 variables:
 $ ACE_CD143_Angiotensin_Converti  : num  2 1.56 1.52 1.68 2.4 ...
 $ ACTH_Adrenocorticotropic_Hormon : num  -1.386 -1.386 -1.715 -1.609 -0.968 ...
 $ AXL                             : num  1.098 0.683 -0.145 0.683 0.191 ...
 $ Adiponectin                     : num  -5.36 -5.02 -5.81 -5.12 -4.78 ...
 $ Alpha_1_Antichymotrypsin        : num  1.74 1.46 1.19 1.28 2.13 ...
 $ Alpha_1_Antitrypsin             : num  -12.6 -11.9 -13.6 -15.5 -11.1 ...
 $ Alpha_1_Microglobulin           : num  -2.58 -3.24 -2.88 -3.17 -2.34 ...
 $ Alpha_2_Macroglobulin           : num  -72.7 -154.6 -136.5 -98.4 -144.9 ...
 $ Angiopoietin_2_ANG_2            : num  1.065 0.742 0.833 0.916 0.956 ...
 $ Angiotensinogen                 : num  2.51 2.46 1.98 2.38 2.86 ...
 $ Apolipoprotein_A_IV             : num  -1.43 -1.66 -1.66 -2.12 -1.17 ...
 $ Apolipoprotein_A1               : num  -7.4 -7.05 -7.68 -8.05 -6.73 ...
 $ Apolipoprotein_A2               : num  -0.2614 -0.8675 -0.6539 -1.2379 0.0953 ...
 $ Apolipoprotein_B                : num  -4.62 -6.75 -3.98 -6.52 -3.38 ...
 $ Apolipoprotein_CI               : num  -1.273 -1.273 -1.715 -1.966 -0.755 ...
 $ Apolipoprotein_CIII             : num  -2.31 -2.34 -2.75 -3 -1.51 ...
 $ Apolipoprotein_D                : num  2.08 1.34 1.34 1.44 1.63 ...
 $ Apolipoprotein_E                : num  3.75 3.1 2.75 2.37 3.07 ...
 $ Apolipoprotein_H                : num  -0.157 -0.575 -0.345 -0.532 0.663 ...
 $ B_Lymphocyte_Chemoattractant_BL : num  2.3 1.67 1.67 1.98 2.3 ...
 $ BMP_6                           : num  -2.2 -1.73 -2.06 -1.98 -1.24 ...
 $ Beta_2_Microglobulin            : num  0.693 0.47 0.336 0.642 0.336 ...
 $ Betacellulin                    : int  34 53 49 52 67 51 41 42 58 59 ...
 $ C_Reactive_Protein              : num  -4.07 -6.65 -8.05 -6.21 -4.34 ...
 $ CD40                            : num  -0.796 -1.273 -1.242 -1.124 -0.924 ...
 $ CD5L                            : num  0.0953 -0.6733 0.0953 -0.3285 0.3633 ...
 $ Calbindin                       : num  33.2 25.3 22.2 23.5 21.8 ...
 $ Calcitonin                      : num  1.386 3.611 2.116 -0.151 1.308 ...
 $ CgA                             : num  398 466 348 334 443 ...
 $ Clusterin_Apo_J                 : num  3.56 3.04 2.77 2.83 3.04 ...
 $ Complement_3                    : num  -10.4 -16.1 -16.1 -13.2 -12.8 ...
 $ Complement_Factor_H             : num  3.57 3.6 4.47 3.1 7.25 ...
 $ Connective_Tissue_Growth_Factor : num  0.531 0.588 0.642 0.531 0.916 ...
 $ Cortisol                        : num  10 12 10 14 11 13 4.9 13 12 17 ...
 $ Creatine_Kinase_MB              : num  -1.71 -1.75 -1.38 -1.65 -1.63 ...
 $ Cystatin_C                      : num  9.04 9.07 8.95 9.58 8.98 ...
 $ EGF_R                           : num  -0.135 -0.37 -0.733 -0.422 -0.621 ...
 $ EN_RAGE                         : num  -3.69 -3.82 -4.76 -2.94 -2.36 ...
 $ ENA_78                          : num  -1.35 -1.36 -1.39 -1.37 -1.34 ...
 $ Eotaxin_3                       : int  53 62 62 44 64 57 64 64 64 70 ...
 $ FAS                             : num  -0.0834 -0.5276 -0.6349 -0.478 -0.1278 ...
 $ FSH_Follicle_Stimulation_Hormon : num  -0.652 -1.627 -1.563 -0.59 -0.976 ...
 $ Fas_Ligand                      : num  3.1 2.98 1.36 2.54 4.04 ...
 $ Fatty_Acid_Binding_Protein      : num  2.521 2.248 0.906 0.624 2.635 ...
 $ Ferritin                        : num  3.33 3.93 3.18 3.14 2.69 ...
 $ Fetuin_A                        : num  1.281 1.194 1.411 0.742 2.152 ...
 $ Fibrinogen                      : num  -7.04 -8.05 -7.2 -7.8 -6.98 ...
 $ GRO_alpha                       : num  1.38 1.37 1.41 1.37 1.4 ...
 $ Gamma_Interferon_induced_Monokin: num  2.95 2.72 2.76 2.89 2.85 ...
 $ Glutathione_S_Transferase_alpha : num  1.064 0.867 0.889 0.708 1.236 ...
 $ HB_EGF                          : num  6.56 8.75 7.75 5.95 7.25 ...
 $ HCC_4                           : num  -3.04 -4.07 -3.65 -3.82 -3.15 ...
 $ Hepatocyte_Growth_Factor_HGF    : num  0.5878 0.5306 0.0953 0.4055 0.5306 ...
 $ I_309                           : num  3.43 3.14 2.4 3.37 3.76 ...
 $ ICAM_1                          : num  -0.1908 -0.462 -0.462 -0.8573 0.0972 ...
 $ IGF_BP_2                        : num  5.61 5.35 5.18 5.42 5.42 ...
 $ IL_11                           : num  5.12 4.94 4.67 6.22 7.07 ...
 $ IL_13                           : num  1.28 1.27 1.27 1.31 1.31 ...
 $ IL_16                           : num  4.19 2.88 2.62 2.44 4.74 ...
 $ IL_17E                          : num  5.73 6.71 4.15 4.7 4.2 ...
 $ IL_1alpha                       : num  -6.57 -8.05 -8.18 -7.6 -6.94 ...
 $ IL_3                            : num  -3.24 -3.91 -4.65 -4.27 -3 ...
 $ IL_4                            : num  2.48 2.4 1.82 1.48 2.71 ...
 $ IL_5                            : num  1.099 0.693 -0.248 0.788 1.163 ...
 $ IL_6                            : num  0.2694 0.0962 0.1857 -0.3712 -0.072 ...
 $ IL_6_Receptor                   : num  0.6428 0.4312 0.0967 0.5752 0.0967 ...
 $ IL_7                            : num  4.81 3.71 1.01 2.34 4.29 ...
 $ IL_8                            : num  1.71 1.68 1.69 1.72 1.76 ...
 $ IP_10_Inducible_Protein_10      : num  6.24 5.69 5.05 5.6 6.37 ...
 $ IgA                             : num  -6.81 -6.38 -6.32 -7.62 -4.65 ...
 $ Insulin                         : num  -0.626 -0.943 -1.447 -1.485 -0.3 ...
 $ Kidney_Injury_Molecule_1_KIM_1  : num  -1.2 -1.2 -1.19 -1.23 -1.16 ...
 $ LOX_1                           : num  1.7 1.53 1.16 1.22 1.36 ...
 $ Leptin                          : num  -1.529 -1.466 -1.662 -1.269 -0.915 ...
 $ Lipoprotein_a                   : num  -4.27 -4.93 -5.84 -4.99 -2.94 ...
 $ MCP_1                           : num  6.74 6.85 6.77 6.78 6.72 ...
 $ MCP_2                           : num  1.981 1.809 0.401 1.981 2.221 ...
 $ MIF                             : num  -1.24 -1.9 -2.3 -1.66 -1.9 ...
 $ MIP_1alpha                      : num  4.97 3.69 4.05 4.93 6.45 ...
 $ MIP_1beta                       : num  3.26 3.14 2.4 3.22 3.53 ...
 $ MMP_2                           : num  4.48 3.78 2.87 2.97 3.69 ...
 $ MMP_3                           : num  -2.21 -2.47 -2.3 -1.77 -1.56 ...
 $ MMP10                           : num  -3.27 -3.65 -2.73 -4.07 -2.62 ...
 $ MMP7                            : num  -3.774 -5.968 -4.03 -6.856 -0.222 ...
 $ Myoglobin                       : num  -1.897 -0.755 -1.386 -1.139 -1.772 ...
 $ NT_proBNP                       : num  4.55 4.22 4.25 4.11 4.47 ...
 $ NrCAM                           : num  5 5.21 4.74 4.97 5.2 ...
 $ Osteopontin                     : num  5.36 6 5.02 5.77 5.69 ...
 $ PAI_1                           : num  1.0035 -0.0306 0.4384 0 0.2523 ...
 $ PAPP_A                          : num  -2.9 -2.81 -2.94 -2.79 -2.94 ...
 $ PLGF                            : num  4.44 4.03 4.51 3.43 4.8 ...
 $ PYY                             : num  3.22 3.14 2.89 2.83 3.66 ...
 $ Pancreatic_polypeptide          : num  0.579 0.336 -0.892 -0.821 0.262 ...
 $ Prolactin                       : num  0 -0.5108 -0.1393 -0.0408 0.1823 ...
 $ Prostatic_Acid_Phosphatase      : num  -1.62 -1.74 -1.64 -1.74 -1.7 ...
 $ Protein_S                       : num  -1.78 -2.46 -2.26 -2.7 -1.66 ...
 $ Pulmonary_and_Activation_Regulat: num  -0.844 -2.303 -1.661 -1.109 -0.562 ...
 $ RANTES                          : num  -6.21 -6.94 -6.65 -5.99 -6.32 ...
 $ Resistin                        : num  -16.5 -16 -16.5 -13.5 -11.1 ...
  [list output truncated]

modeldata documentation built on July 14, 2021, 5:07 p.m.