steroidogenic_toxicity | R Documentation |
A set of in vitro assays are used to quantify the risk of reproductive toxicity via the disruption of steroidogenic pathways.
H295R cells were used to measure the effect with two sets of assay results. The first includes a set of protein measurements on: cytochrome P450 enzymes ("cyp"s), STAR, and 3BHSD2. The second include hormone measurements for DHEA, progesterone, testosterone, and cortisol.
Columns:
class
: factor (levels: 'toxic' and 'nontoxic')
cyp_11a1
: numeric
cyp_11b1
: numeric
cyp_11b2
: numeric
cyp_17a1
: numeric
cyp_19a1
: numeric
cyp_21a1
: numeric
hsd3b2
: numeric
star
: numeric
progesterone
: numeric
testosterone
: numeric
dhea
: numeric
cortisol
: numeric
A tibble with columns
class
: factor(levels: toxic and nontoxic)
cyp_11a1
: numeric
cyp_11b1
: numeric
cyp_11b2
: numeric
cyp_17a1
: numeric
cyp_19a1
: numeric
cyp_21a1
: numeric
hsd3b2
: numeric
star
: numeric
progesterone
: numeric
testosterone
: numeric
dhea
: numeric
cortisol
: numeric
Maglich, J. M., Kuhn, M., Chapin, R. E., & Pletcher, M. T. (2014). More than just hormones: H295R cells as predictors of reproductive toxicity. Reproductive Toxicology, 45, 77-86.
data(steroidogenic_toxicity)
str(steroidogenic_toxicity)
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