Description Usage Arguments Details Value Author(s) References See Also Examples
This function computes subjectspecific or overall cumulative transition hazards for each of the possible transitions in the multistate model. If requested, also the variances and covariances of the estimated cumulative transition hazards are calculated.
1 2 3 4 5 6 7 
object 
A 
newdata 
A data frame with the same variable names as those that
appear in the 
variance 
A logical value indicating whether the (co)variances of the
subjectspecific transition hazards should be computed. Default is

vartype 
A character string specifying the type of variances to be
computed (so only needed if 
trans 
Transition matrix describing the states and transitions in the
multistate model. See 
The data frame needs to have one row for each transition in the multistate
model. An additional column strata
(numeric) is needed to describe
for each transition to which stratum it belongs. The name has to be
strata
, even if in the original coxph
call another variable
was used. For details refer to de Wreede, Fiocco & Putter (2010). So far,
the results have been checked only for the "breslow"
method of
dealing with ties in coxph
, so this is
recommended.
An object of class "msfit"
, which is a list containing
Haz 
A data frame with 
varHaz 
A data frame with

trans 
The transition matrix used 
Hein Putter H.Putter@lumc.nl
Putter H, Fiocco M, Geskus RB (2007). Tutorial in biostatistics: Competing risks and multistate models. Statistics in Medicine 26, 2389–2430.
Therneau TM, Grambsch PM (2000). Modeling Survival Data: Extending the Cox Model. Springer, New York.
de Wreede LC, Fiocco M, and Putter H (2010). The mstate package for estimation and prediction in non and semiparametric multistate and competing risks models. Computer Methods and Programs in Biomedicine 99, 261–274.
de Wreede LC, Fiocco M, and Putter H (2011). mstate: An R Package for the Analysis of Competing Risks and MultiState Models. Journal of Statistical Software, Volume 38, Issue 7.
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23  # transition matrix for illnessdeath model
tmat < trans.illdeath()
# data in wide format, for transition 1 this is dataset E1 of
# Therneau & Grambsch (2000)
tg < data.frame(illt=c(1,1,6,6,8,9),ills=c(1,0,1,1,0,1),
dt=c(5,1,9,7,8,12),ds=c(1,1,1,1,1,1),
x1=c(1,1,1,0,0,0),x2=c(6:1))
# data in long format using msprep
tglong < msprep(time=c(NA,"illt","dt"),status=c(NA,"ills","ds"),
data=tg,keep=c("x1","x2"),trans=tmat)
# events
events(tglong)
table(tglong$status,tglong$to,tglong$from)
# expanded covariates
tglong < expand.covs(tglong,c("x1","x2"))
# Cox model with different covariate
cx < coxph(Surv(Tstart,Tstop,status)~x1.1+x2.2+strata(trans),
data=tglong,method="breslow")
summary(cx)
# new data, to check whether results are the same for transition 1 as
# those in appendix E.1 of Therneau & Grambsch (2000)
newdata < data.frame(trans=1:3,x1.1=c(0,0,0),x2.2=c(0,1,0),strata=1:3)
msfit(cx,newdata,trans=tmat)

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