lin_cmt: concentrations from a linear compartment model

In nlmixr: Nonlinear Mixed Effects Models in Population PK/PD

concentrations from a linear compartment model

Description

concentrations from a linear compartment model by close-form solutions

Usage

lin_cmt(
  obs_time,
  dose_time,
  dose,
  Tinf,
  params,
  oral,
  infusion,
  ncmt,
  parameterization
)

Arguments

obs_time	times at which an observation is desired
dose_time	times at which doses are given
dose	a vector of doses
Tinf	a vector of infusion duration
params	model-appropriate parameters per parameterization
oral	logical, whether oral absorption is true
infusion	logical, whether infusion is true
ncmt	number of compartments
parameterization	type of parameterization, 1=clearance/volume, 2=micro-constants

Details

This is used by some of the internal nlmixr routines, for example the low level nlme estimation with nlmixr. With the nlmixr functions you should use 'linCmt()' instead. It is documented at https://nlmixrdevelopment.github.io/RxODE/articles/RxODE-model-types.html#solved-compartment-models

Value

calculated concentrations

nlmixr documentation built on March 27, 2022, 5:05 p.m.