warfarin: Warfarin PK/PD data

In nlmixr2data: Nonlinear Mixed Effects Models in Population PK/PD, Data

Warfarin PK/PD data

Description

Warfarin PK/PD data

Usage

warfarin

Format

A data frame with 519 rows and 9 columns

id

Patient identifier (n=32)

time

Time (h)

amt

Total drug administered (mg)

dv

Warfarin concentrations (mg/L) or PCA measurement

dvid

Dependent identifier Information (cp: Dose or PK, pca: PCA, factor)

evid

Event identifier

wt

Weight (kg)

age

Age (yr)

sex

Sex (male or female, factor)

Source

Funaki T, Holford N, Fujita S (2018). Population PKPD analysis using nlmixr2 and NONMEM. PAGJA 2018

References

O'Reilly RA, Aggeler PM, Leong LS. Studies of the coumarin anticoagulant drugs: The pharmacodynamics of warfarin in man. Journal of Clinical Investigation 1963; 42(10): 1542-1551

O'Reilly RA, Aggeler PM. Studies on coumarin anticoagulant drugs Initiation of warfarin therapy without a loading dose. Circulation 1968; 38: 169-177.

See Also

Other nlmixr2 datasets: Bolus_1CPTMM, Bolus_1CPT, Bolus_2CPTMM, Bolus_2CPT, Infusion_1CPTMM, Infusion_1CPT, Infusion_2CPTMM, Infusion_2CPT, Oral_1CPTMM, Oral_1CPT, Oral_2CPTMM, Oral_2CPT, Wang2007, mavoglurant, nimoData, nmtest, pheno_sd, rats, theo_md, theo_sd, wbcSim

nlmixr2data documentation built on June 22, 2024, 7:12 p.m.