Pbc3: Pbc3 data
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Pbc3	R Documentation

Pbc3 data

Description

PBC3 was a multi-centre randomized clinical trial conducted in six European hospitals. Between 1 Jan. 1983 and 1 Jan. 1987, 349 patients with the liver disease primary biliary cirrhosis (PBC) were randomized to either treatment with Cyclosporin A (CyA, 176 patients) or placebo (173 patients). The purpose of the trial was to study the effect of treatment on the survival time. However, during the course of the trial an increased use of liver transplantation for patients with this disease made the investigators redefine the main response variable to be time to “failure of medical treatment” defined as either death or liver transplantation. Patients were then followed from randomization until treatment failure, drop-out or 1 Jan, 1989; 61 patients died (CyA: 30, placebo: 31), another 29 were transplanted (CyA: 14, placebo: 15) and 4 patients were lost to follow-up before 1 Jan. 1989. At entry a number of clinical, biochemical and histological variables, including serum bilirubin, serum albumin, sex, age were recorded.

Format

A data frame with 349 observations on the following 15 variables.

ptno: patient identification
unit: hospital (1: Hvidovre, 2: London, 3: Copenhagen, 4: Barcelona, 5: Munich, 6: Lyon)
tment: treatment (0: placebo, 1: CyA)
sex: (1: males, 0: females)
age: age in years
stage: histological stage (1, 2, 3, 4)
gibleed: previous gastrointestinal bleeding (1: yes, 0: no)
crea: creatinine (micromoles/L)
alb: albumin (g/L)
bili: bilirubin (micromoles/L)
alkph: alkaline phosphatase (IU/L)
asptr: aspartate transaminase (IU/L)
weight: body weight (kg)
days: observation time (days)
status: status at observation time (0: censored, 1: liver transplantation, 2 : dead)