Description Usage Arguments Value References Examples
Thall and Simon's criterion function for determining the trial decision boundaries based on the posterior probability.
1 | PostP(x, n, a, b, p0)
|
x |
the number of responses among n patients treated by the experimental drug. |
n |
the number of patients treated by the experimental drug. |
a |
the hyperparameter (shape1) of the Beta prior for the experimental drug. |
b |
the hyperparameter (shape2) of the Beta prior for the experimental drug. |
p0 |
the prespecified reseponse rate. |
prob |
the posterior probability: Pr(p > p_0 | X=x) |
Berry, S. M., Carlin, B. P., Lee, J. J., & Muller, P. (2010). Bayesian adaptive methods for clinical trials. CRC press.
Thall, P. F., Simon, R. (1994). Practical Bayesian guidelines for phase IIB clinical trials. Biometrics 50: 337-349.
Yin, G. (2013). Clinical Trial Design: Bayesian and Frequentist Adaptive Methods. New York: Wiley.
1 | PostP(8,15,1,1,0.8)
|
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