Description Usage Arguments Value References Examples

Thall and Simon's criterion function for determining the trial decision boundaries based on the posterior probability.

1 | ```
PostP(x, n, a, b, p0)
``` |

`x` |
the number of responses among |

`n` |
the number of patients treated by the experimental drug. |

`a` |
the hyperparameter (shape1) of the Beta prior for the experimental drug. |

`b` |
the hyperparameter (shape2) of the Beta prior for the experimental drug. |

`p0` |
the prespecified reseponse rate. |

`prob` |
the posterior probability: |

Berry, S. M., Carlin, B. P., Lee, J. J., & Muller, P. (2010).
*Bayesian adaptive methods for clinical trials.*
CRC press.

Thall, P. F., Simon, R. (1994).
Practical Bayesian guidelines for phase IIB clinical trials.
*Biometrics* **50**: 337-349.

Yin, G. (2013).
*Clinical Trial Design: Bayesian and Frequentist Adaptive Methods.*
New York: Wiley.

1 | ```
PostP(8,15,1,1,0.8)
``` |

ph2bye documentation built on May 29, 2017, 9:08 a.m.

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