Description Usage Arguments Value References Examples
The prior function to calculate the Beta prior parameters
1 |
type |
type of prior information: "MeanVar" uses mean and variance, "Optimist" uses (ORR) mean, "ORRN" uses ORR and smaple size, "ORRW" uses ORR and CI width. |
mu |
prior(ORR) mean. |
v |
prior variance |
N |
prior sample size. |
W |
prior confidence interval width. |
init |
initial value to solve the nonlinear equations for "ORRW" type. |
parameters |
the vector of Beta parameters: a and b |
Thall, P. F., Simon, R. (1994). Practical Bayesian guidelines for phase IIB clinical trials. Biometrics 50: 337-349.
Mayo, M. S., & Gajewski, B. J. (2004). Bayesian sample size calculations in phase II clinical trials using informative conjugate priors. Controlled clinical trials 25(2): 157-167.
Tan, S. B., & Machin, D. (2002). Bayesian two-stage designs for phase II clinical trials. Statistics in medicine 21(14): 1991-2012. New York: Wiley.
1 2 3 4 |
Loading required package: animation
sh: 1: cannot create /dev/null: Permission denied
sh: 1: cannot create /dev/null: Permission denied
Loading required package: nleqslv
a b
1.08 4.32
a b
1.2 1.8
a b
3.2 9.8
Algorithm parameters
--------------------
Method: Broyden Global strategy: double dogleg (initial trust region = -2)
Maximum stepsize = 1.79769e+308
Scaling: fixed
ftol = 1e-08 xtol = 1e-08 btol = 0.01 cndtol = 1e-12
Iteration report
----------------
Iter Jac Lambda Eta Dlt0 Dltn Fnorm Largest |f|
0 1.684634e-01 4.969173e-01
1 N(3.3e-02) N 0.4151 20.0025 20.0025 5.273271e-02 2.897546e-01
2 B(4.3e-02) N 0.8380 4.5700 4.5700 4.368695e-02 2.770594e-01
3 B(1.2e-02) W 0.4647 0.9011 4.5700 4.5700 2.946025e-02 2.392425e-01
4 B(1.7e-02) N 0.9760 3.1102 3.1102 1.520551e-02 1.740295e-01
5 B(2.0e-02) N 0.9973 0.6522 0.3220 1.559704e-02 1.765722e-01
5 W 0.3388 0.9973 0.3220 0.1610 1.383794e-02 1.663423e-01
6 B(5.5e-02) C 0.9990 0.1610 0.1610 1.239374e-02 1.574280e-01
7 B(4.4e-01) C 0.9986 0.1610 0.3220* 1.100110e-02 1.483263e-01
7 C 0.9986 0.3220 0.6439* 9.664322e-03 1.390274e-01
7 C 0.9986 0.6439 1.2878* 7.181440e-03 1.198116e-01
7 C 0.9986 1.2878 2.5757* 3.191233e-03 7.870810e-02
7 C 0.9986 2.5757 5.1513 2.326860e-03 6.629149e-02
8 B(3.0e-01) N 0.6277 2.1793 4.3585 4.082996e-04 2.179620e-02
9 B(3.1e-01) N 0.9778 0.4097 0.4097 1.388167e-04 1.417817e-02
10 B(2.3e-01) N 0.9488 0.1972 0.3944 8.994026e-06 3.351068e-03
11 B(2.7e-01) N 0.9577 0.0545 0.1090 2.131957e-07 5.427505e-04
12 B(2.5e-01) N 0.9515 0.0080 0.0159 9.466863e-10 3.735577e-05
13 B(2.6e-01) N 0.9221 0.0006 0.0012 2.977033e-12 2.043897e-06
14 B(2.6e-01) N 0.9309 0.0000 0.0001 4.442816e-15 7.921770e-08
15 B(2.6e-01) N 0.9340 0.0000 0.0000 1.024213e-19 3.802499e-10
a b
1.582918 6.331671
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