pwr_overall_pois: Power Calculation from Sample Size

In preference: 2-Stage Preference Trial Design and Analysis

Description

Calculates the study power to detect a set of effects given a particular sample size in a two-stage randomized clinical trial

Usage

pwr_overall_pois(
  N,
  phi,
  lambda11,
  lambda22,
  lambda1,
  lambda2,
  alpha = 0.05,
  theta = 0.5,
  xi = 1,
  nstrata = 1
)

Arguments

N	overall study sample size.
phi	the proportion of patients preferring treatment 1. Should be numeric value between 0 and 1. If study is stratified, should be vector with length equal to the number of strata in the study.
lambda11	response mean of patients choosing to receive treatment 1 in the choice arm. Should be numeric value larger than 0. If study is stratified, should be vector with length equal to the number of strata in the study.
lambda22	response mean of patients choosing to receive treatment 2 in the choice arm. Should be numeric value larger than 0. If study is stratified, should be vector with length equal to the number of strata in the study.
lambda1	response mean of patients randomized to receive treatment 1 in the random arm. Should be numeric value larger than 0. If study is stratified, should be vector with length equal to the number of strata in the study.
lambda2	response mean of patients randomized to receive treatment 2 in the random arm. Should be numeric value larger than 0. If study is stratified, should be vector with length equal to the number of strata in the study.
alpha	desired type I error rate.
theta	proportion of patients assigned to choice arm in the initial randomization. Should be numeric value between 0 and 1 (default=0.5).
xi	a numeric vector of the proportion of patients in each stratum. Length of vector should equal the number of strata in the study and sum of vector should be 1. All vector elements should be numeric values between 0 and 1. Default is 1 (i.e. unstratified design).
nstrata	number of strata. Default is 1 (i.e. unstratified design).

Examples

# Unstratified
pwr_overall_pois(N=400, phi=0.5, lambda11=0.8, lambda22=0.5, lambda1=0.5, lambda2=0.4)
# Stratified
pwr_overall_pois(N=400, phi=c(0.5,0.5), lambda11=c(0.7,0.8), lambda22=c(0.4,0.4), 
lambda1=c(0.5,0.4), lambda2=c(0.2,0.3), xi=c(0.3,0.7), nstrata=2)

preference documentation built on Sept. 13, 2020, 5:08 p.m.