pseval: Methods for Evaluating Principal Surrogates of Treatment Response

Contains the core methods for the evaluation of principal surrogates in a single clinical trial. Provides a flexible interface for defining models for the risk given treatment and the surrogate, the models for integration over the missing counterfactual surrogate responses, and the estimation methods. Estimated maximum likelihood and pseudo-score can be used for estimation, and the bootstrap for inference. A variety of post-estimation summary methods are provided, including print, summary, plot, and testing.

AuthorMichael C Sachs [aut, cre], Erin E Gabriel [aut]
Date of publication2016-09-23 22:53:05
MaintainerMichael C Sachs <sachsmc@gmail.com>
LicenseMIT + file LICENSE
Version1.3.0

View on CRAN

Man pages

add_bootstrap: Bootstrap resampling parameters

add_estimate: Estimate parameters

add_integration: Integration models

add_riskmodel: Add risk model to a psdesign object

calc_risk: Calculate the risk and functions of the risk

calc_STG: Calculate the Standardized total gain

empirical_TE: Compute the empirical Treatment Efficacy

empirical_VE: Compute the empirical Treatment Efficacy

expand_augdata: Expand augmented data using the integration function

generate_example_data: Generate sample data used for testing

integrate_bivnorm: Bivariate normal integration models for the missing S(1)

integrate_nonparametric: Nonparametric integration model for the missing S(1)

integrate_parametric: Parametric integration model for the missing S(1)

integrate_semiparametric: Semiparametric integration model using the location-scale...

plot.psdesign: Plot summary statistics for a psdesign object

plus-.ps: Modify a psdesign object by adding on new components.

print.psdesign: Concisely print information about a psdesign object

ps_bootstrap: Estimate parameters from a specified model using bootstrap...

psdesign: Specify a design for a principal surrogate evaluation

ps_estimate: Estimate parameters from a specified model using estimated...

pseudo_score: Estimate parameters from a specified model using pseudo-score

risk_binary: Risk model for binary outcome

riskcalc: Calculate risks with handlers for survival data

risk_continuous: Risk model for continuous outcome

risk_exponential: Exponential risk model for time to event outcome

risk.logit: Logit link function

risk_poisson: Poisson risk model for count outcomes

risk.probit: Probit link function

risk_weibull: Weibull risk model for time to event outcome

sp_locscale: Fit the semi-parametric location-scale model

stg: Compute the standardized total gain

summarize_bs: Summarize bootstrap samples

summary.psdesign: Summary method for psdesign objects

TE: Treatment efficacy contrast functions

verify_trt: Check that a variable is suitable for using as binary...

wem_test: Test for wide effect modificiation

Files in this package

pseval
pseval/inst
pseval/inst/CITATION
pseval/inst/doc
pseval/inst/doc/cheatsheet.pdf
pseval/inst/doc/introduction.R
pseval/inst/doc/introduction.html
pseval/inst/doc/introduction.Rmd
pseval/tests
pseval/tests/simulation-study.R
pseval/tests/testthat.R
pseval/tests/testthat
pseval/tests/testthat/test-bootstrap.R
pseval/tests/testthat/test-estimation.R
pseval/NAMESPACE
pseval/NEWS
pseval/R
pseval/R/gen-test-data.R pseval/R/integrate.R pseval/R/pseudo-score.R pseval/R/summarize.R pseval/R/risk.R pseval/R/design.R pseval/R/post-estimation.R pseval/R/print.R pseval/R/estimate.R pseval/R/pseval-constructors.R
pseval/vignettes
pseval/vignettes/psreferences.bib
pseval/vignettes/introduction.Rmd
pseval/README.md
pseval/MD5
pseval/build
pseval/build/vignette.rds
pseval/DESCRIPTION
pseval/man
pseval/man/stg.Rd pseval/man/summarize_bs.Rd pseval/man/add_riskmodel.Rd pseval/man/riskcalc.Rd pseval/man/empirical_VE.Rd pseval/man/verify_trt.Rd pseval/man/integrate_semiparametric.Rd pseval/man/risk_weibull.Rd pseval/man/TE.Rd pseval/man/psdesign.Rd pseval/man/add_integration.Rd pseval/man/plus-.ps.Rd pseval/man/risk_binary.Rd pseval/man/ps_estimate.Rd pseval/man/risk_poisson.Rd pseval/man/integrate_bivnorm.Rd pseval/man/risk_exponential.Rd pseval/man/integrate_parametric.Rd pseval/man/integrate_nonparametric.Rd pseval/man/print.psdesign.Rd pseval/man/plot.psdesign.Rd pseval/man/expand_augdata.Rd pseval/man/generate_example_data.Rd pseval/man/risk.logit.Rd pseval/man/risk_continuous.Rd pseval/man/calc_risk.Rd pseval/man/add_estimate.Rd pseval/man/ps_bootstrap.Rd pseval/man/empirical_TE.Rd pseval/man/sp_locscale.Rd pseval/man/summary.psdesign.Rd pseval/man/add_bootstrap.Rd pseval/man/calc_STG.Rd pseval/man/wem_test.Rd pseval/man/pseudo_score.Rd pseval/man/risk.probit.Rd
pseval/LICENSE

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