Data from a mouse intercross experiment on gut length, including both sexes. All individuals carry the Sox10Dom mutation.
An object of class
A mouse intercross between C3HeBFeJ (C3) and C57BL/6J (B6), with one F1 parent carrying the Sox10Dom mutation. There are 1068 mice from reciprocal intercrosses. Over 2000 mice were generated, but only those individuals heterozygous at Sox10Dom were genotyped and included in the data set. Sox10 is on chromosome 15, and so that chromosome exhibits an unusual segregation pattern. Some mice received the mutation from their mother and some from their father.
The primary phenotype here is gut length (in cm). The phenotype
cross indicates the cross used to generate an animal.
E. Michelle Southard-Smith, Division of Genetic Medicine, Department of Medicine, Vanderbilt University School of Medicine, firstname.lastname@example.org
Owens, S. E., Broman, K. W., Wiltshire, T., Elmore, J. B., Bradley, K. M., Smith, J. R. and Southard-Smith, E. M. (2005) Genome-wide linkage identifies novel modifier loci of aganglionosis in the Sox10Dom model of Hirschsprung disease. Hum. Mol. Genet. 14, 1549–1558.
Broman, K. W., Sen, 'S, Owens, S. E., Manichaikul, A., Southard-Smith, E. M. and Churchill G. A. (2006) The X chromosome in quantitative trait locus mapping. Genetics 174, 2151–2158.
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