nf1: Neurofibromatosis type 1 backcross data

In qtlbook: Datasets for the R/qtl Book

Description

Data from a backcross experiment on neurofibromatosis type I. All individuals carry the NPcis mutation, received either from their mother or from their father.

Usage

nf1

Format

An object of class cross. See qtl::read.cross() for details.

Details

Backcrosses (C57BL/6J x A/J) x C57BL/6J and C57BL/6J x (A/J x C57BL/6J) with a total of 254 individuals. Individuals received the NPcis mutation from either their mother or their father (indicated by the phenotype from.mom. The major phenotype, affected indicates whether the mice were affected (1) or unaffected (0) with neurofibromatosis type 1.

References

Reilly, K. M., Broman, K. W., Bronson, R. T., Tsang, S., Loisel, D. A., Christy, E. S., Sun, Z., Diehl, J., Munroe, D. J. and Tuskan, R. G. (2006) An imprinted locus epistatically influences Nstr1 and Nstr2 to control resistance to nerve sheath tumors in a neurofibromatosis type 1 mouse model. Cancer Research 66, 62–68. #' @source Karlyne Reilly, Mouse Cancer Genetics Program, National Cancer Institute at Frederick, [e-mail]

See Also

link{gutlength} link{iron}, link{myocard}, link{ovar}, link{trout}

Examples

data(nf1)
library(qtl)
plot(nf1)

qtlbook documentation built on June 28, 2019, 5:02 p.m.