# lrm: Logistic Regression Model In rms: Regression Modeling Strategies

## Description

Fit binary and proportional odds ordinal logistic regression models using maximum likelihood estimation or penalized maximum likelihood estimation. See cr.setup for how to fit forward continuation ratio models with lrm.

For the print method, format of output is controlled by the user previously running options(prType="lang") where lang is "plain" (the default), "latex", or "html".

## Usage

  1 2 3 4 5 6 7 8 9 10 lrm(formula, data=environment(formula), subset, na.action=na.delete, method="lrm.fit", model=FALSE, x=FALSE, y=FALSE, linear.predictors=TRUE, se.fit=FALSE, penalty=0, penalty.matrix, tol=1e-7, strata.penalty=0, var.penalty=c('simple','sandwich'), weights, normwt, scale=FALSE, ...) ## S3 method for class 'lrm' print(x, digits=4, strata.coefs=FALSE, coefs=TRUE, title='Logistic Regression Model', ...) 

## Arguments

 formula a formula object. An offset term can be included. The offset causes fitting of a model such as logit(Y=1) = Xβ + W, where W is the offset variable having no estimated coefficient. The response variable can be any data type; lrm converts it in alphabetic or numeric order to an S factor variable and recodes it 0,1,2,... internally. data data frame to use. Default is the current frame. subset logical expression or vector of subscripts defining a subset of observations to analyze na.action function to handle NAs in the data. Default is na.delete, which deletes any observation having response or predictor missing, while preserving the attributes of the predictors and maintaining frequencies of deletions due to each variable in the model. This is usually specified using options(na.action="na.delete"). method name of fitting function. Only allowable choice at present is lrm.fit. model causes the model frame to be returned in the fit object x causes the expanded design matrix (with missings excluded) to be returned under the name x. For print, an object created by lrm. y causes the response variable (with missings excluded) to be returned under the name y. linear.predictors causes the predicted X beta (with missings excluded) to be returned under the name linear.predictors. When the response variable has more than two levels, the first intercept is used. se.fit causes the standard errors of the fitted values to be returned under the name se.fit. penalty The penalty factor subtracted from the log likelihood is 0.5 β' P β, where β is the vector of regression coefficients other than intercept(s), and P is penalty factors * penalty.matrix and penalty.matrix is defined below. The default is penalty=0 implying that ordinary unpenalized maximum likelihood estimation is used. If penalty is a scalar, it is assumed to be a penalty factor that applies to all non-intercept parameters in the model. Alternatively, specify a list to penalize different types of model terms by differing amounts. The elements in this list are named simple, nonlinear, interaction and nonlinear.interaction. If you omit elements on the right of this series, values are inherited from elements on the left. Examples: penalty=list(simple=5, nonlinear=10) uses a penalty factor of 10 for nonlinear or interaction terms. penalty=list(simple=0, nonlinear=2, nonlinear.interaction=4) does not penalize linear main effects, uses a penalty factor of 2 for nonlinear or interaction effects (that are not both), and 4 for nonlinear interaction effects. penalty.matrix specifies the symmetric penalty matrix for non-intercept terms. The default matrix for continuous predictors has the variance of the columns of the design matrix in its diagonal elements so that the penalty to the log likelhood is unitless. For main effects for categorical predictors with c categories, the rows and columns of the matrix contain a c-1 \times c-1 sub-matrix that is used to compute the sum of squares about the mean of the c parameter values (setting the parameter to zero for the reference cell) as the penalty component for that predictor. This makes the penalty independent of the choice of the reference cell. If you specify penalty.matrix, you may set the rows and columns for certain parameters to zero so as to not penalize those parameters. Depending on penalty, some elements of penalty.matrix may be overridden automatically by setting them to zero. The penalty matrix that is used in the actual fit is penalty \times diag(pf) \times penalty.matrix \times diag(pf), where pf is the vector of square roots of penalty factors computed from penalty by Penalty.setup in rmsMisc. If you specify penalty.matrix you must specify a nonzero value of penalty or no penalization will be done. tol singularity criterion (see lrm.fit) strata.penalty scalar penalty factor for the stratification factor, for the experimental strat variable var.penalty the type of variance-covariance matrix to be stored in the var component of the fit when penalization is used. The default is the inverse of the penalized information matrix. Specify var.penalty="sandwich" to use the sandwich estimator (see below under var), which limited simulation studies have shown yields variances estimates that are too low. weights a vector (same length as y) of possibly fractional case weights normwt set to TRUE to scale weights so they sum to the length of y; useful for sample surveys as opposed to the default of frequency weighting scale set to TRUE to subtract means and divide by standard deviations of columns of the design matrix before fitting, and to back-solve for the un-normalized covariance matrix and regression coefficients. This can sometimes make the model converge for very large sample sizes where for example spline or polynomial component variables create scaling problems leading to loss of precision when accumulating sums of squares and crossproducts. ... arguments that are passed to lrm.fit, or from print, to prModFit digits number of significant digits to use strata.coefs set to TRUE to print the (experimental) strata coefficients coefs specify coefs=FALSE to suppress printing the table of model coefficients, standard errors, etc. Specify coefs=n to print only the first n regression coefficients in the model. title a character string title to be passed to prModFit

## Value

The returned fit object of lrm contains the following components in addition to the ones mentioned under the optional arguments.

 call calling expression freq table of frequencies for Y in order of increasing Y stats vector with the following elements: number of observations used in the fit, maximum absolute value of first derivative of log likelihood, model likelihood ratio chi-square, d.f., P-value, c index (area under ROC curve), Somers' D_{xy}, Goodman-Kruskal gamma, Kendall's tau-a rank correlations between predicted probabilities and observed response, the Nagelkerke R^2 index, the Brier score computed with respect to Y > its lowest level, the g-index, gr (the g-index on the odds ratio scale), and gp (the g-index on the probability scale using the same cutoff used for the Brier score). Probabilities are rounded to the nearest 0.0002 in the computations or rank correlation indexes. In the case of penalized estimation, the "Model L.R." is computed without the penalty factor, and "d.f." is the effective d.f. from Gray's (1992) Equation 2.9. The P-value uses this corrected model L.R. chi-square and corrected d.f. The score chi-square statistic uses first derivatives which contain penalty components. fail set to TRUE if convergence failed (and maxiter>1) coefficients estimated parameters var estimated variance-covariance matrix (inverse of information matrix). If penalty>0, var is either the inverse of the penalized information matrix (the default, if var.penalty="simple") or the sandwich-type variance - covariance matrix estimate (Gray Eq. 2.6) if var.penalty="sandwich". For the latter case the simple information-matrix - based variance matrix is returned under the name var.from.info.matrix. effective.df.diagonal is returned if penalty>0. It is the vector whose sum is the effective d.f. of the model (counting intercept terms). u vector of first derivatives of log-likelihood deviance -2 log likelihoods (counting penalty components) When an offset variable is present, three deviances are computed: for intercept(s) only, for intercepts+offset, and for intercepts+offset+predictors. When there is no offset variable, the vector contains deviances for the intercept(s)-only model and the model with intercept(s) and predictors. est vector of column numbers of X fitted (intercepts are not counted) non.slopes number of intercepts in model penalty see above penalty.matrix the penalty matrix actually used in the estimation

## Author(s)

Frank Harrell
Department of Biostatistics, Vanderbilt University
fh@fharrell.com

## References

Le Cessie S, Van Houwelingen JC: Ridge estimators in logistic regression. Applied Statistics 41:191–201, 1992.

Verweij PJM, Van Houwelingen JC: Penalized likelihood in Cox regression. Stat in Med 13:2427–2436, 1994.

Gray RJ: Flexible methods for analyzing survival data using splines, with applications to breast cancer prognosis. JASA 87:942–951, 1992.

Shao J: Linear model selection by cross-validation. JASA 88:486–494, 1993.

Verweij PJM, Van Houwelingen JC: Crossvalidation in survival analysis. Stat in Med 12:2305–2314, 1993.

Harrell FE: Model uncertainty, penalization, and parsimony. ISCB Presentation on UVa Web page, 1998.

lrm.fit, predict.lrm, rms.trans, rms, glm, latex.lrm, residuals.lrm, na.delete, na.detail.response, pentrace, rmsMisc, vif, cr.setup, predab.resample, validate.lrm, calibrate, Mean.lrm, gIndex, prModFit
  1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 #Fit a logistic model containing predictors age, blood.pressure, sex #and cholesterol, with age fitted with a smooth 5-knot restricted cubic #spline function and a different shape of the age relationship for males #and females. As an intermediate step, predict mean cholesterol from #age using a proportional odds ordinal logistic model # n <- 1000 # define sample size set.seed(17) # so can reproduce the results age <- rnorm(n, 50, 10) blood.pressure <- rnorm(n, 120, 15) cholesterol <- rnorm(n, 200, 25) sex <- factor(sample(c('female','male'), n,TRUE)) label(age) <- 'Age' # label is in Hmisc label(cholesterol) <- 'Total Cholesterol' label(blood.pressure) <- 'Systolic Blood Pressure' label(sex) <- 'Sex' units(cholesterol) <- 'mg/dl' # uses units.default in Hmisc units(blood.pressure) <- 'mmHg' #To use prop. odds model, avoid using a huge number of intercepts by #grouping cholesterol into 40-tiles ch <- cut2(cholesterol, g=40, levels.mean=TRUE) # use mean values in intervals table(ch) f <- lrm(ch ~ age) options(prType='latex') print(f, coefs=4) # write latex code to console m <- Mean(f) # see help file for Mean.lrm d <- data.frame(age=seq(0,90,by=10)) m(predict(f, d)) # Repeat using ols f <- ols(cholesterol ~ age) predict(f, d) # Specify population model for log odds that Y=1 L <- .4*(sex=='male') + .045*(age-50) + (log(cholesterol - 10)-5.2)*(-2*(sex=='female') + 2*(sex=='male')) # Simulate binary y to have Prob(y=1) = 1/[1+exp(-L)] y <- ifelse(runif(n) < plogis(L), 1, 0) cholesterol[1:3] <- NA # 3 missings, at random ddist <- datadist(age, blood.pressure, cholesterol, sex) options(datadist='ddist') fit <- lrm(y ~ blood.pressure + sex * (age + rcs(cholesterol,4)), x=TRUE, y=TRUE) # x=TRUE, y=TRUE allows use of resid(), which.influence below # could define d <- datadist(fit) after lrm(), but data distribution # summary would not be stored with fit, so later uses of Predict # or summary.rms would require access to the original dataset or # d or specifying all variable values to summary, Predict, nomogram anova(fit) p <- Predict(fit, age, sex) ggplot(p) # or plot() ggplot(Predict(fit, age=20:70, sex="male")) # need if datadist not used print(cbind(resid(fit,"dfbetas"), resid(fit,"dffits"))[1:20,]) which.influence(fit, .3) # latex(fit) #print nice statement of fitted model # #Repeat this fit using penalized MLE, penalizing complex terms #(for nonlinear or interaction effects) # fitp <- update(fit, penalty=list(simple=0,nonlinear=10), x=TRUE, y=TRUE) effective.df(fitp) # or lrm(y ~ \dots, penalty=\dots) #Get fits for a variety of penalties and assess predictive accuracy #in a new data set. Program efficiently so that complex design #matrices are only created once. set.seed(201) x1 <- rnorm(500) x2 <- rnorm(500) x3 <- sample(0:1,500,rep=TRUE) L <- x1+abs(x2)+x3 y <- ifelse(runif(500)<=plogis(L), 1, 0) new.data <- data.frame(x1,x2,x3,y)[301:500,] # for(penlty in seq(0,.15,by=.005)) { if(penlty==0) { f <- lrm(y ~ rcs(x1,4)+rcs(x2,6)*x3, subset=1:300, x=TRUE, y=TRUE) # True model is linear in x1 and has no interaction X <- f$x # saves time for future runs - don't have to use rcs etc. Y <- f$y # this also deletes rows with NAs (if there were any) penalty.matrix <- diag(diag(var(X))) Xnew <- predict(f, new.data, type="x") # expand design matrix for new data Ynew <- new.data$y } else f <- lrm.fit(X,Y, penalty.matrix=penlty*penalty.matrix) # cat("\nPenalty :",penlty,"\n") pred.logit <- f$coef[1] + (Xnew %*% f$coef[-1]) pred <- plogis(pred.logit) C.index <- somers2(pred, Ynew)["C"] Brier <- mean((pred-Ynew)^2) Deviance<- -2*sum( Ynew*log(pred) + (1-Ynew)*log(1-pred) ) cat("ROC area:",format(C.index)," Brier score:",format(Brier), " -2 Log L:",format(Deviance),"\n") } #penalty=0.045 gave lowest -2 Log L, Brier, ROC in test sample for S+ # #Use bootstrap validation to estimate predictive accuracy of #logistic models with various penalties #To see how noisy cross-validation estimates can be, change the #validate(f, \dots) to validate(f, method="cross", B=10) for example. #You will see tremendous variation in accuracy with minute changes in #the penalty. This comes from the error inherent in using 10-fold #cross validation but also because we are not fixing the splits. #20-fold cross validation was even worse for some #indexes because of the small test sample size. Stability would be #obtained by using the same sample splits for all penalty values #(see above), but then we wouldn't be sure that the choice of the #best penalty is not specific to how the sample was split. This #problem is addressed in the last example. # penalties <- seq(0,.7,length=3) # really use by=.02 index <- matrix(NA, nrow=length(penalties), ncol=11, dimnames=list(format(penalties), c("Dxy","R2","Intercept","Slope","Emax","D","U","Q","B","g","gp"))) i <- 0 for(penlty in penalties) { cat(penlty, "") i <- i+1 if(penlty==0) { f <- lrm(y ~ rcs(x1,4)+rcs(x2,6)*x3, x=TRUE, y=TRUE) # fit whole sample X <- f$x Y <- f$y penalty.matrix <- diag(diag(var(X))) # save time - only do once } else f <- lrm(Y ~ X, penalty=penlty, penalty.matrix=penalty.matrix, x=TRUE,y=TRUE) val <- validate(f, method="boot", B=20) # use larger B in practice index[i,] <- val[,"index.corrected"] } par(mfrow=c(3,3)) for(i in 1:9) { plot(penalties, index[,i], xlab="Penalty", ylab=dimnames(index)[[2]][i]) lines(lowess(penalties, index[,i])) } options(datadist=NULL) # Example of weighted analysis x <- 1:5 y <- c(0,1,0,1,0) reps <- c(1,2,3,2,1) lrm(y ~ x, weights=reps) x <- rep(x, reps) y <- rep(y, reps) lrm(y ~ x) # same as above # #Study performance of a modified AIC which uses the effective d.f. #See Verweij and Van Houwelingen (1994) Eq. (6). Here AIC=chisq-2*df. #Also try as effective d.f. equation (4) of the previous reference. #Also study performance of Shao's cross-validation technique (which was #designed to pick the "right" set of variables, and uses a much smaller #training sample than most methods). Compare cross-validated deviance #vs. penalty to the gold standard accuracy on a 7500 observation dataset. #Note that if you only want to get AIC or Schwarz Bayesian information #criterion, all you need is to invoke the pentrace function. #NOTE: the effective.df( ) function is used in practice # ## Not run: for(seed in c(339,777,22,111,3)){ # study performance for several datasets set.seed(seed) n <- 175; p <- 8 X <- matrix(rnorm(n*p), ncol=p) # p normal(0,1) predictors Coef <- c(-.1,.2,-.3,.4,-.5,.6,-.65,.7) # true population coefficients L <- X %*% Coef # intercept is zero Y <- ifelse(runif(n)<=plogis(L), 1, 0) pm <- diag(diag(var(X))) #Generate a large validation sample to use as a gold standard n.val <- 7500 X.val <- matrix(rnorm(n.val*p), ncol=p) L.val <- X.val %*% Coef Y.val <- ifelse(runif(n.val)<=plogis(L.val), 1, 0) # Penalty <- seq(0,30,by=1) reps <- length(Penalty) effective.df <- effective.df2 <- aic <- aic2 <- deviance.val <- Lpenalty <- single(reps) n.t <- round(n^.75) ncv <- c(10,20,30,40) # try various no. of reps in cross-val. deviance <- matrix(NA,nrow=reps,ncol=length(ncv)) #If model were complex, could have started things off by getting X, Y #penalty.matrix from an initial lrm fit to save time # for(i in 1:reps) { pen <- Penalty[i] cat(format(pen),"") f.full <- lrm.fit(X, Y, penalty.matrix=pen*pm) Lpenalty[i] <- pen* t(f.full$coef[-1]) %*% pm %*% f.full$coef[-1] f.full.nopenalty <- lrm.fit(X, Y, initial=f.full$coef, maxit=1) info.matrix.unpenalized <- solve(f.full.nopenalty$var) effective.df[i] <- sum(diag(info.matrix.unpenalized %*% f.full$var)) - 1 lrchisq <- f.full.nopenalty$stats["Model L.R."] # lrm does all this penalty adjustment automatically (for var, d.f., # chi-square) aic[i] <- lrchisq - 2*effective.df[i] # pred <- plogis(f.full$linear.predictors) score.matrix <- cbind(1,X) * (Y - pred) sum.u.uprime <- t(score.matrix) %*% score.matrix effective.df2[i] <- sum(diag(f.full$var %*% sum.u.uprime)) aic2[i] <- lrchisq - 2*effective.df2[i] # #Shao suggested averaging 2*n cross-validations, but let's do only 40 #and stop along the way to see if fewer is OK dev <- 0 for(j in 1:max(ncv)) { s <- sample(1:n, n.t) cof <- lrm.fit(X[s,],Y[s], penalty.matrix=pen*pm)$coef pred <- cof[1] + (X[-s,] %*% cof[-1]) dev <- dev -2*sum(Y[-s]*pred + log(1-plogis(pred))) for(k in 1:length(ncv)) if(j==ncv[k]) deviance[i,k] <- dev/j } # pred.val <- f.full$coef[1] + (X.val %*% f.full$coef[-1]) prob.val <- plogis(pred.val) deviance.val[i] <- -2*sum(Y.val*pred.val + log(1-prob.val)) } postscript(hor=TRUE) # along with graphics.off() below, allow plots par(mfrow=c(2,4)) # to be printed as they are finished plot(Penalty, effective.df, type="l") lines(Penalty, effective.df2, lty=2) plot(Penalty, Lpenalty, type="l") title("Penalty on -2 log L") plot(Penalty, aic, type="l") lines(Penalty, aic2, lty=2) for(k in 1:length(ncv)) { plot(Penalty, deviance[,k], ylab="deviance") title(paste(ncv[k],"reps")) lines(supsmu(Penalty, deviance[,k])) } plot(Penalty, deviance.val, type="l") title("Gold Standard (n=7500)") title(sub=format(seed),adj=1,cex=.5) graphics.off() } ## End(Not run) #The results showed that to obtain a clear picture of the penalty- #accuracy relationship one needs 30 or 40 reps in the cross-validation. #For 4 of 5 samples, though, the super smoother was able to detect #an accurate penalty giving the best (lowest) deviance using 10-fold #cross-validation. Cross-validation would have worked better had #the same splits been used for all penalties. #The AIC methods worked just as well and are much quicker to compute. #The first AIC based on the effective d.f. in Gray's Eq. 2.9 #(Verweij and Van Houwelingen (1994) Eq. 5 (note typo)) worked best.