scDiffCom: Differential Analysis of Intercellular Communication from scRNA-Seq Data

Analysis tools to investigate changes in intercellular communication from scRNA-seq data. Using a Seurat object as input, the package infers which cell-cell interactions are present in the dataset and how these interactions change between two conditions of interest (e.g. young vs old). It relies on an internal database of ligand-receptor interactions (available for both human and mouse) that have been gathered from several published studies. Detection and differential analyses rely on permutation tests. The package also contains several tools to perform over-representation analysis and visualize the results. See Lagger, C. et al. (2021) <doi:10.1101/2021.08.13.456238> for a full description of the methodology.

Getting started

Package details

AuthorCyril Lagger [aut, cre] (<https://orcid.org/0000-0003-1701-6896>), Eugen Ursu [aut], Anais Equey [ctb]
MaintainerCyril Lagger <lagger.cyril@gmail.com>
LicenseMIT + file LICENSE
Version0.1.0
URL https://cyrillagger.github.io/scDiffCom/
Package repositoryView on CRAN
Installation Install the latest version of this package by entering the following in R:
install.packages("scDiffCom")

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scDiffCom documentation built on Aug. 17, 2021, 9:07 a.m.