bound.parameters: Forces parameter estimates between defined boundaries.

In scaRabee: Optimization Toolkit for Pharmacokinetic-Pharmacodynamic Models

Description

bound.parameters is a utility function called during estimation runs. It forces the parameter estimates to remain within the boundaries defined in the .csv file of initial estimates. bound.parameters is typically not called directly by users.

Usage

  bound.parameters(x = NULL,
                   lb = NULL,
                   ub = NULL)

Arguments

x	A vector of p parameter estimates.
lb	A vector of p lower boundaries.
ub	A vector of p upper boundaries.

Value

Returns a vector of p values. The ith element of the returned vector is:

• x[i] if lb[i] < x[i] < ub[i]

• lb[i] if x[i] <= lb[i]

• ub[i] if ub[i] <= x[i]

Author(s)

Sebastien Bihorel ([e-mail])

Examples

bound.parameters(seq(1:5), lb=rep(3,5), ub=rep(4,5))

# The following call should return an error message
bound.parameters(1, lb=rep(3,5), ub=rep(4,5))

scaRabee documentation built on Feb. 4, 2022, 5:07 p.m.