Description Details Author(s) References
Translates antibody levels measured in a (cross-sectional) population sample into an estimate of the frequency with which seroconversions (infections) occur in the sampled population.
For detailed documentation type the following in the R console:
vignette("installation", package = "seroincidence")
vignette("tutorial", package = "seroincidence")
vignette("methodology", package = "seroincidence")
Author: Peter Teunis <p.teunis@emory.edu>
Author: Jan van Eijkeren
Contributor: Daniel Lewandowski <daniel@nextpagesoft.net>
Maintainer: Chantal Quinten <seroincidence@ecdc.europa.eu>
Methods for estimating seroincidence
Teunis, P. F., van Eijkeren, J. C., Ang, C. W., van Duynhoven, Y. T., Simonsen, J. B., Strid, M. A., van Pelt, W.
"Biomarker dynamics: estimating infection rates from serological data"
Statistics in Medicine 31, no. 20 (September 9, 2012): 2240–48. doi:10.1002/sim.5322.
Simonsen, J., Molbak, K., Falkenhorst, G., Krogfelt, K. A., Linneberg, A., Teunis, P. F.
"Estimation of incidences of infectious diseases based on antibody measurements"
Statistics in Medicine 28, no. 14 (June 30, 2009): 1882–95. doi:10.1002/sim.3592.
Applications
Monge, S., Teunis, P. F., Friesema, I., Franz, E., Ang, W., van Pelt, W., Mughini-Gras, L.
"Immune response-eliciting exposure to Campylobacter vastly exceeds the incidence of clinically
overt campylobacteriosis but is associated with similar risk factors: A nationwide serosurvey in the Netherlands"
Journal of Infection, 2018, 1–7, doi:10.1016/j.jinf.2018.04.016
Kretzschmar, M., Teunis, P. F., Pebody, R. G.
"Incidence and reproduction numbers of pertussis: estimates from serological and social contact data in five European countries"
PLoS Medicine 7, no. 6 (June 1, 2010):e1000291. doi:10.1371/journal.pmed.1000291.
Simonsen, J., Strid, M. A., Molbak, K., Krogfelt, K. A., Linneberg, A., Teunis, P.
"Sero-epidemiology as a tool to study the incidence of Salmonella infections in humans"
Epidemiology and Infection 136, no. 7 (July 1, 2008): 895–902. doi:10.1017/S0950268807009314
Simonsen, J., Teunis, P. F., van Pelt, W., van Duynhoven, Y., Krogfelt, K. A., Sadkowska-Todys, M., Molbak K.
"Usefulness of seroconversion rates for comparing infection pressures between countries"
Epidemiology and Infection, April 12, 2010, 1–8. doi:10.1017/S0950268810000750.
Falkenhorst, G., Simonsen, J., Ceper, T. H., van Pelt, W., de Valk, H., Sadkowska-Todys, M., Zota, L., Kuusi, M., Jernberg, C., Rota, M. C., van Duynhoven, Y. T., Teunis, P. F., Krogfelt, K. A., Molbak, K.
"Serological cross-sectional studies on salmonella incidence in eight European countries: no correlation with incidence of reported cases"
BMC Public Health 12, no. 1 (July 15, 2012): 523–23. doi:10.1186/1471-2458-12-523.
Teunis, P. F., Falkenhorst, G., Ang, C. W., Strid, M. A., De Valk, H., Sadkowska-Todys, M., Zota, L., Kuusi, M., Rota, M. C., Simonsen, J. B., Molbak, K., Van Duynhoven, Y. T., van Pelt, W.
"Campylobacter seroconversion rates in selected countries in the European Union"
Epidemiology and Infection 141, no. 10 (2013): 2051–57. doi:10.1017/S0950268812002774.
de Melker, H. E., Versteegh, F. G., Schellekens, J. F., Teunis, P. F., Kretzschmar, M.
"The incidence of Bordetella pertussis infections estimated in the population from a combination of serological surveys"
The Journal of Infection 53, no. 2 (August 1, 2006): 106–13. doi:10.1016/j.jinf.2005.10.020
Quantification of seroresponse
de Graaf, W. F., Kretzschmar, M. E., Teunis, P. F., Diekmann, O.
"A two-phase within-host model for immune response and its application to serological profiles of pertussis"
Epidemics 9 (2014):1–7. doi:10.1016/j.epidem.2014.08.002.
Berbers, G. A., van de Wetering, M. S., van Gageldonk, P. G., Schellekens, J. F., Versteegh, F. G., Teunis, P.F.
"A novel method for evaluating natural and vaccine induced serological responses to Bordetella pertussis antigens"
Vaccine 31, no. 36 (August 12, 2013): 3732–38. doi:10.1016/j.vaccine.2013.05.073.
Versteegh, F. G., Mertens, P. L., de Melker, H. E., Roord, J. J., Schellekens, J. F., Teunis, P. F.
"Age-specific long-term course of IgG antibodies to pertussis toxin after symptomatic infection with Bordetella pertussis"
Epidemiology and Infection 133, no. 4 (August 1, 2005): 737–48.
Teunis, P. F., van der Heijden, O. G., de Melker, H. E., Schellekens, J. F., Versteegh, F. G., Kretzschmar, M. E.
"Kinetics of the IgG antibody response to pertussis toxin after infection with B. pertussis"
Epidemiology and Infection 129, no. 3 (December 10, 2002):479. doi:10.1017/S0950268802007896.
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