Provides functions to implement sgRSEA (single-guide RNA Set Enrichment Analysis), which is a robust test for identification of essential genes from genetic screening data using CRISPR (clustered regularly interspaced short palindromic repeats) and Cas9 (CRISPR-associated nuclease 9) system.
|Author||Jungsik Noh, Beibei Chen|
|Date of publication||2015-06-15 17:08:25|
|Maintainer||Jungsik Noh <Jungsik.Noh@UTSouthwestern.edu>|
melanoma808: A subset of CRISPR/Cas9 knockout screening data on melanoma...
plotNScores: Plot histograms of normalized gene scores
plotScores: Plot histograms of gene scores
sgCount: Generate a raw sgRNA read count table from fastq files
sgRSEA: Perform a permutation test which computes gene scores and...
sgRSEA.mean: Perform a permutation test similar to sgRSEA
UQnormalize: Upper-quartile/total-count normalization of raw sgRNA read...