sgRSEA.mean: Perform a permutation test similar to sgRSEA

Description Usage Arguments Details Value References See Also

Description

Perform the similar method to sgRSEA using a simple average instead of the maxmean statistic as gene level statistics. This method is referred as T_{mean} in Noh et al. (2015+).

Usage

1
sgRSEA.mean(dat, multiplier = 50, r.seed = NULL)

Arguments

dat

A data.frame where rows represent sgRNAs and columns are the sgRNA name (1st), targeting gene name (2nd), and sgRNA read counts under treatment (3rd) and control (4th) condition.

multiplier

The number of permutations.

r.seed

A random seed to control the randomness of the permutation.

Details

Arguments and Value are the same as sgRSEA().

Value

Returns the same list as sgRSEA().

References

Noh, J., Chen, B., Xiao, G. and Xie, Y. (2015+). A robust test for identification of essential genes from CRISPR/Cas9 knockout screens.

See Also

sgRSEA


sgRSEA documentation built on May 2, 2019, 2:47 p.m.

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