Description Usage Arguments Value See Also
Apply the upper-quartile/total-count normalization to raw sgRNA read count data. In addition, this function can merge pairs of sgRNA read counts in different replications when CRISPR/Cas9 knockout screens are implemented with a few replications.
1 2 |
raw.count |
A data.frame with raw sgRNA read counts. Rows represent sgRNAs and columns are the sgRNA names (1st), targeting gene names (2nd), and raw counts under multiple experimental conditions. |
trt |
A character vector of column names of |
ctrl |
A character vector of column names of |
round |
Default is |
add.one |
Default is |
print |
Default is |
Returns a data.frame with sgRNA name, targeting gene name and normalized counts under treatment and control.
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