est_statistic: estimate Z score at a single SNP
In simGWAS: Fast Simulation of Large Case-Control GWAS Summary Statistics

Description Usage Arguments Details Value Author(s)

View source: R/zscore.R

Wrapper function to run est_zscore for all snps in snps

1	est_statistic(N0, N1, snps, W, gamma.W, freq, GenoProbList)

`N0`	The number of Y=0
`N1`	The number of Y=1
`snps`	The snps at which we wish to compute the expected Z Score
`W`	The true causal SNPs (these need not be in "snps")
`gamma.W`	The odds ratios of effect of the true causal SNPs (not including gamma0, the intercept term)
`freq`	Frequencies of SNP appearances (computed using snphap)
`GenoProbList`	An list of objects giving the probability of seeing each X,W genotype vector

Assumes we have a list, GenoProbList, giving the GenoProb values for each X.

The expected Z Score for SNP X, assuming the causal SNPs are W

Mary Fortune and Chris Wallace

simGWAS documentation built on Aug. 22, 2019, 9:03 a.m.

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README.md Simulating GWAS data, a walkthrough

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