est_zscore: estimate Z score at a single SNP
In simGWAS: Fast Simulation of Large Case-Control GWAS Summary Statistics

Description Usage Arguments Details Value Author(s)

View source: R/zscore.R

Estimates the expected Z Score for a single SNP

1	est_zscore(N0, N1, Ufactor, powerfactor, freq, GenoProbXW)

`N0`	The number of Y=0
`N1`	The number of Y=1
`Ufactor`	The constant factor used to compute the expectation of U
`powerfactor`	The constant factor used to compute the expectation of the genotype of X to some power
`freq`	Frequencies of SNP appearances (computed using snphap)
`GenoProbXW`	An object giving the probability of seeing each X,W genotype vector

Assumes the input CVs, and the relationship, gamma, between them and the trait of interest

Assumes we have already generated GenoProbXW for all X

The expected Z Score for SNP X, assuming the causal SNPs are W

Mary Fortune and Chris Wallace

simGWAS documentation built on Aug. 22, 2019, 9:03 a.m.

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README.md Simulating GWAS data, a walkthrough

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