Description Author(s) References

Newly developed methods for the estimation of several probabilities in an illness-death model. The package can be used to obtain nonparametric and semiparametric estimates for: transition probabilities, occupation probabilities, cumulative incidence function and the sojourn time distributions. Additionally, it is possible to fit proportional hazards regression models in each transition of the Illness-Death Model. Several auxiliary functions are also provided which can be used for marginal estimation of the survival functions.

Luis Meira-Machado, Marta Sestelo and Gustavo Soutinho.

Maintainer: Marta Sestelo, sestelo@uvigo.es

Aalen O. O., Johansen S. (1978) An Empirical Transition Matrix for Nonhomogeneous Markov Chains Based on Censored Observations. Scandinavian Journal of Statistics, 5(3), 141–150.

Cao R., Lopez-de Ullibarri I., Janssen P., Veraverbeke N. (2005) Presmoothed kaplan-meier and nelsonaalen estimators. Journal of Nonparametric Statistics, 17, 31–56.

de Una-Alvarez J. and Meira-Machado L. (2015). Nonparametric estimation of transition probabilities in a non-Markov illness-death model: a comparative study. Biometrics, 71, 364–375.

Geskus R.B. (2011). Cause-specific cumulative incidence estimation and the fine and gray model under both left truncation and right censoring. Biometrics, 67, 39–49.

Meira-Machado L. F., de Una-Alvarez J. and Cadarso-Suarez C. (2006). Nonparametric estimation of transition probabilities in a non-Markov illness-death model. Lifetime Data Anal 12(3), 325–344.

Satten G.A. and Datta S. (2002) Marginal estimation for multi-stage models: waiting time distributions and competing risks analyses. Statistics in Medicine, 21, 3–19.

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