DVR_all_ref_Logan: Non-invasive reference Logan method for all ROIs in tac data

In tacmagic: Positron Emission Tomography Time-Activity Curve Analysis

Description

This calculates the DVR using the non-invasive reference Logan method for all TACs in a supplied tac file. It uses DVR_ref_Logan.

Usage

DVR_all_ref_Logan(
  tac_data,
  ref,
  k2prime,
  t_star,
  error = 0.1,
  method = "trapz",
  ...
)

Arguments

tac_data	The time-activity curve data from tac_roi()
ref	Required – The reference region, e.g. "cerebellum"
k2prime	Required – A fixed value for k2' must be specified (e.g. 0.2)
t_star	Required – If 0, t* will be calculated using find_t_star()
error	For find_t_star()
method	Method of integration, "trapz" or "integrate"
...	When called from tm_batch, unused parameters may be supplied

Value

Data frame with calculated DVRs for all ROIs

References

Logan, J., Fowler, J. S., Volkow, N. D., Wang, G.-J., Ding, Y.-S., & Alexoff, D. L. (1996). Distribution Volume Ratios without Blood Sampling from Graphical Analysis of PET Data. Journal of Cerebral Blood Flow & Metabolism, 16(5), 834-840. https://doi.org/10.1097/00004647-199609000-00008

See Also

Other Logan plot functions: DVR_ref_Logan(), dvr(), plot.ref_Logan()

Examples

f <- system.file("extdata", "AD06.tac", package="tacmagic")
fv <- system.file("extdata", "AD06_TAC.voistat", package="tacmagic")
AD06_tac <- load_tac(f, format="PMOD")
AD06_volume <- load_vol(fv, format="voistat")
AD06 <- tac_roi(tac=AD06_tac, volumes=AD06_volume, ROI_def=roi_ham_pib(),  
                merge=FALSE, PVC=FALSE)  

AD06_DVR <- DVR_all_ref_Logan(AD06, ref="cerebellum", k2prime=0.2, t_star=23)

tacmagic documentation built on Dec. 15, 2020, 5:13 p.m.