summarize_ancova.md
In tern: Create Common TLGs Used in Clinical Trials

h_ancova works with healthy input

Code
  res
Output
  # A tibble: 3 x 6
    Species    estimate std.error    df conf.low conf.high
    <chr>         <dbl>     <dbl> <dbl>    <dbl>     <dbl>
  1 setosa         6.15    0.337    143     5.49      6.82
  2 versicolor     5.72    0.0668   143     5.59      5.85
  3 virginica      5.41    0.149    143     5.11      5.70

s_ancova works with healthy input

Code
  res
Output
  $n
  [1] 50

  $lsmean
  [1] 5.717409
  attr(,"label")
  [1] "Adjusted Mean"

  $lsmean_diff
  [1] -0.4374138
  attr(,"label")
  [1] "Difference in Adjusted Means"

  $lsmean_diff_ci
  [1] -1.4268150  0.5519873
  attr(,"label")
  [1] "99% CI"

  $pval
  [1] 0.2503574
  attr(,"label")
  [1] "p-value"

s_ancova works with interaction and .in_ref_col = TRUE

Code
  res
Output
  $n
  [1] 20

  $lsmean
  [1] 4.362642
  attr(,"label")
  [1] "Adjusted Mean"

  $lsmean_diff
  character(0)
  attr(,"label")
  [1] "Difference in Adjusted Means"

  $lsmean_diff_ci
  character(0)
  attr(,"label")
  [1] "95% CI"

  $pval
  character(0)
  attr(,"label")
  [1] "p-value"

summarize_ancova works with healthy inputs

Code
  res
Output
                                                  setosa     versicolor       virginica   
                                                  (N=50)       (N=50)           (N=50)    
  ————————————————————————————————————————————————————————————————————————————————————————
  Unadjusted comparison                                                                   
    n                                               50           50               50      
    Mean                                           5.01         5.94             6.59     
    Difference in Means                                         0.93             1.58     
      95% CI                                                (0.73, 1.13)     (1.38, 1.79) 
      p-value                                                 <0.0001          <0.0001    
  Adjusted comparison (covariates Petal.Length)                                           
    n                                               50           50               50      
    Adjusted Mean                                  7.08         5.48             4.97     
    Difference in Adjusted Means                               -1.60            -2.12     
      95% CI                                               (-1.98, -1.22)   (-2.66, -1.58)
      p-value                                                 <0.0001          <0.0001

summarize_ancova works with irregular arm levels

Code
  res
Output
                              ARM A       ARM A Subgroup   ARM C 
                             (N=69)           (N=73)       (N=58)
  ———————————————————————————————————————————————————————————————
  Unadjusted comparison                                          
    n                          552             584          464  
    Mean                      0.01             0.01        -0.05 
    Difference in Means       0.06             0.06              
      95% CI              (-0.07, 0.19)   (-0.06, 0.19)          
      p-value                0.3442           0.3186

Code
  res
Output
                              ARM A       ARM B (x)   ARM C 
                             (N=69)        (N=73)     (N=58)
  ——————————————————————————————————————————————————————————
  Unadjusted comparison                                     
    n                          552           584       464  
    Mean                      0.01          0.01      -0.05 
    Difference in Means       0.06                          
      95% CI              (-0.07, 0.19)                     
      p-value                0.3442

Code
  res
Output
                                   10mg/kg      20mg/kg         30mg/kg   
  ————————————————————————————————————————————————————————————————————————
  ARMCD                                                                   
    n                                69           73              58      
    Adjusted Mean                   6.30         6.75            6.16     
    Difference in Adjusted Means                 0.45            -0.14    
      95% CI                                 (-0.70, 1.60)   (-1.36, 1.08)
      p-value                                   0.4433          0.8214