titeIR: Isotonic Designs for Phase 1 Trials with Late-Onset Toxicities

Functions to design phase 1 trials using an isotonic regression based design incorporating time-to-event information. Simulation and design functions are available, which incorporate information about followup and DLTs, and apply isotonic regression to devise estimates of DLT probability.

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Package details

AuthorLee McDaniel [aut, cre]
MaintainerLee McDaniel <[email protected]>
Package repositoryView on CRAN
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titeIR documentation built on Sept. 29, 2018, 1:03 a.m.