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titeIR: Isotonic Designs for Phase 1 Trials with Late-Onset Toxicities
Functions to design phase 1 trials using an isotonic regression based design incorporating time-to-event information. Simulation and design functions are available, which incorporate information about followup and DLTs, and apply isotonic regression to devise estimates of DLT probability.
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Package details |
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| Author | Lee McDaniel [aut, cre] |
| Maintainer | Lee McDaniel <lmcda4@lsuhsc.edu> |
| License | GPL-3 |
| Version | 0.1.0 |
| Package repository | View on CRAN |
| Installation |
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