Description Usage Arguments Value See Also Examples
Simulates trials based on the TITE-IR design.
1 2 | isotitesim(PI, target, n, nsim, obswin = 1, rate = 1, safety = 0.05,
accrual = "poisson", restrict = TRUE)
|
PI |
A vector of true toxicity probabilities at each dose |
target |
Target DLT rate |
n |
Sample size of the trial |
nsim |
Number of trial replicates |
obswin |
The observation window with respect to which the MTD is defined |
rate |
Patient arrival rate: expected number of arrivals per observation window |
safety |
The safety factor to prevent overly aggressive escalation |
accrual |
Specify the accrual distribution. Can be either |
restrict |
If |
Object of type isotite
which provides results from TITE-IR simulations
isotitedose
for dose recommendation
1 2 | isotitesim(PI = c(0.05, 0.10, 0.20, 0.30, 0.50, 0.70),
target = 1/3, n = 24, nsim = 10, obswin = 6, rate = 12)
|
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