Description Usage Arguments Value See Also Examples
Calculate the next dose assignment for a TITE-IR design.
1 2 | isotitedose(followup, DLT, assignment, obswin, doses, target = 1/3,
safety = 0.05)
|
followup |
A vector of followup times |
DLT |
A vector of DLT results. |
assignment |
a vector of dose assignments. Doses should be labeled in consecutive integers from 1 to number of dose levels. |
obswin |
The observation window with respect to which the MTD is defined. |
doses |
An integer providing the number of doses. |
target |
Target DLT rate |
safety |
The safety factor to prevent overly aggressive escalation |
an integer specifying the recommended dose level
isotitesim
for simulations
1 2 | isotitedose(followup = c(6, 5, 4, 3, 2, 1), DLT = c(0, 0, 0, 0, 0, 0),
assignment = c(1, 1, 1, 2, 2, 2), obswin = 6, doses = 6)
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