isotitedose: Dose assignment for TITE-IR designs

In titeIR: Isotonic Designs for Phase 1 Trials with Late-Onset Toxicities

Description

Calculate the next dose assignment for a TITE-IR design.

Usage

isotitedose(followup, DLT, assignment, obswin, doses, target = 1/3,
  safety = 0.05)

Arguments

followup	A vector of followup times
DLT	A vector of DLT results. FALSE or 0 is interpreted as no observed DLT and TRUE or 1 is interpreted as observed DLT.
assignment	a vector of dose assignments. Doses should be labeled in consecutive integers from 1 to number of dose levels.
obswin	The observation window with respect to which the MTD is defined.
doses	An integer providing the number of doses.
target	Target DLT rate
safety	The safety factor to prevent overly aggressive escalation

Value

an integer specifying the recommended dose level

See Also

isotitesim for simulations

Examples

isotitedose(followup = c(6, 5, 4, 3, 2, 1), DLT = c(0, 0, 0, 0, 0, 0),
 assignment = c(1, 1, 1, 2, 2, 2), obswin = 6, doses = 6)

titeIR documentation built on May 1, 2019, 9:17 p.m.