LogisticLogNormalSub-class: 'LogisticLogNormalSub'

In 0liver0815/onc-crmpack-test: Object-Oriented Implementation of CRM Designs

Description

LogisticLogNormalSub is the class for a standard logistic model with bivariate (log) normal prior with subtractive dose standardization.

Usage

LogisticLogNormalSub(mean, cov, ref_dose = 0)

Arguments

mean	(numeric) the prior mean vector.
cov	(matrix) the prior covariance matrix.
ref_dose	(number) the reference dose.

Details

The covariate is the dose x minus the reference dose x*, i.e.:

logit[p(x)] = alpha0 + alpha1 * (x - x*),

where p(x) is the probability of observing a DLT for a given dose x. The prior

(alpha0, log(alpha1)) ~ Normal(mean, cov).

See Also

ModelLogNormal, LogisticNormal, LogisticLogNormal, ProbitLogNormal, ProbitLogNormalRel.

Examples

my_model <- LogisticLogNormalSub(
  mean = c(-0.85, 1),
  cov = matrix(c(1, -0.5, -0.5, 1), nrow = 2),
  ref_dose = 50
)

0liver0815/onc-crmpack-test documentation built on Feb. 19, 2022, 12:25 a.m.