consensus_concordants: Generate a Consensus list of Targets

In AliSajid/DrugDiscoveryPanCan: Investigate Drug Targets for Kinase Therapies

Description

This function takes a list of (optionally split) concordance dataframes and returns a ranked list of gene or drug targets that have been chose for their maximal similarity to the signature

Usage

consensus_concordants(
  ...,
  paired = FALSE,
  cutoff = 0.321,
  cell_line = NULL,
  discordant = FALSE
)

Arguments

...	One or Two (see paired) Data Frames with the concordants
paired	Logical indicating whether you split the dataframes by up and down regulated in prior analysis
cutoff	A similarity cutoff value. Defaults to 0.321
cell_line	A character vector of Cell Lines you are interested in.
discordant	Logical indicating whether you want discordant signatures

Value

A tibble with the filtered and deduplicated results

Examples

TRUE

AliSajid/DrugDiscoveryPanCan documentation built on Feb. 4, 2021, 6:31 a.m.