prepare_signature: Prepare an L1000 Signature froma given differential gene...

In AliSajid/DrugDiscoveryPanCan: Investigate Drug Targets for Kinase Therapies

Description

This function takes a differential gene expression output from any pipeline like edgeR or DeSeq2 or any that give you the gene symbol, log_2 fold-change and p-value and transforms that into an L1000 signature for later processing.

Usage

prepare_signature(
  dge,
  gene_column = "Symbol",
  logfc_column = "logFC",
  pval_column = "PValue"
)

Arguments

dge	A dataframe-like object that has the differential gene expression information
gene_column	The name of the column that has gene symbols
logfc_column	The name of the column that has log_2 fold-change values
pval_column	The name of the column that has p-values

Value

A tibble with the L1000 signature.

Examples

TRUE

AliSajid/DrugDiscoveryPanCan documentation built on Feb. 4, 2021, 6:31 a.m.