View source: R/germline_filter.R
Plot expected germline and somatic VAF along with observed somatic VAF. And retrieve the the mutational status infered by the method. Variants found to have an observed VAF below 2 standard deviations below the expected value are considered "subclonal". Those falling in the +/- 2 standard deviation range from the expected VAF are annoatated "neutral". Those with VAF greater than 2 starndard deviation above the expected value are annotated as "artifacts".
1 | germline_filter(mat, purity, alpha = 0.05, plot = TRUE, sample)
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mat.out
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