alphabetr
implements the ALPHABETR (algorithm for pairing alpha-beta T cell receptors) algorithms for obtaining TCR sequence pairs. This approach determines CDR3A/CDR3B pairs from high-throughput sequencing data from repeated samples of antigen-specific T cell populations.
With alphabetr
, you can
You can install
install.packages("alphabetr")
if (packageVersion("devtools") < 1.6) {
install.packages("devtools")
}
devtools::install_github("edwardslee/alphabetr")
If you encounter any bugs, please file an issue.
Please see our paper in PLOS Computational Biology for more details about the algorithm and how it was tested (DOI: 10.1371/journal.pcbi.1005313).
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